Abhishek Singh

TL;DR: The basic background of ASDs, various formulation and process variables influencing the critical quality attributes (CQAs) of the ASDs and aspects of downstream processing are discussed and recent advances in the spray-based drying techniques are mentioned.

TL;DR: Today, the pharmaceutical industry has at its disposal a series of reliable and scalable formulation strategies for poorly soluble drugs, but due to a lack of understanding of the basic physical chemistry behind these strategies, formulation development is still driven by trial and error.

TL;DR: Even though the parameters were not optimized for spray drying all phages, it was demonstrated that spray drying phages with this industrial relevant and scalable set up was possible and the resulting powders had desirable size ranges for pulmonary delivery of phage with dry powder inhalers (DPIs).

TL;DR: In this study, itraconazole-Soluplus solid dispersions with 50% (w/w) drug loading prepared by hot-melt extrusion (HME) were investigated and compression revealed that compression promotes phase separation of solid dispersion.

TL;DR: The variation in drug-polymer miscibility and solid form of the drug in solid dispersions can occur across spray dryer in small-scale manufacturing processes, and the optimization of formulation parameters and spray drying process parameters is imperative to diminish these variations to enhance homogeneity of solid dispersion in laboratory scale spray dryers.