Achim Schnaufer

TL;DR: A picture of highly organized complexes is emerging that shows that the complex that catalyzes the central steps of editing is partitioned into distinct insertion and deletion editing subcomplexes.

TL;DR: Regulated repression of TbMP52 blocks editing, which shows that it is a functional component of the editing complex, indicating that editing is essential in the mammalian stage of the life cycle.

TL;DR: In this paper, the α subunit of the mitochondrial F1-ATP synthase complex was found to be lethal for T. brucei and T. evansi, a closely related species that lacks mitochondrial protein coding genes.

TL;DR: The data available on dyskinetoplasty in trypanosomes is summarized and the roles the mitochondrion and its genome play during the life cycle of T. brucei are revisited, questioning the therapeutic value of attempts to target mitochondrial gene expression with specific drugs.

TL;DR: Nine novel editosome proteins in Trypanosoma brucei are identified by mass spectrometric analysis of functional editosomes that were purified by serial ion exchange/gel permeation chromatography, immunoaffinity chromatography specific to the TbMP63 editosomal protein, or tandem affinity purification based on a tagged RNA editing ligase.