Adalsteinn Gunnlaugsson

TL;DR: There was weak evidence of an increased frequency of acute physician-reported RTOG grade 2 or worse urinary toxicity in the ultra-hypofractionation group at end of radiotherapy, consistent with the physician-evaluated toxicity.

TL;DR: The Statistical Decomposition Algorithm enables a highly accurate MRI only workflow in prostate radiotherapy planning and the dosimetric uncertainties originating from the SDA appear negligible and are notably lower than the uncertainties introduced by variations in patient geometry between imaging sessions.

TL;DR: A strong dose-volume relationship between small bowel volume and radiation enteritis during 5-FU-OXA-based chemoradiotherapy is indicated, indicating the application of maneuvers to minimize small bowel irradiation, such as using a “belly board” or the use of IMRT technique aiming at keeping the small bowelVolume receiving more than 15 Gy under 150 cc.

TL;DR: Results of the study show that the sCT conversion method can be used clinically, with minimal differences between sCT and CT dose distributions for target and relevant organs at risk, and that an MR imaging-only workflow using MriPlanner is robust for a variety of field strengths, vendors, and treatment techniques.

TL;DR: Surgery, radiation therapy and chemotherapy are the key components of rectal cancer therapy and selected patients with recurrent and metastatic disease can be salvaged with surgery but chemotherapy remains the mainstay of therapy for advanced colorectal cancer.