A
Adam Groothuis
Researcher at Massachusetts Institute of Technology
Publications - 26
Citations - 2023
Adam Groothuis is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Neointimal hyperplasia & Stent. The author has an hindex of 19, co-authored 26 publications receiving 1874 citations.
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Journal ArticleDOI
Neointimal thickening after stent delivery of paclitaxel : Change in composition and arrest of growth over six months
Douglas E. Drachman,Elazer R. Edelman,Elazer R. Edelman,Philip Seifert,Adam Groothuis,Danielle Bornstein,Kalpana R Kamath,Maria Palasis,Dachuan Yang,Sepideh H Nott,Campbell Rogers,Campbell Rogers +11 more
TL;DR: Poly(lactide-co-sigma-caprolactone) copolymer-coated stents permit sustained paclitaxel delivery in a manner that virtually abolishes neointimal hyperplasia for months after stent implantation, long after likely completion of drug delivery and polymer degradation.
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Early Feasibility Study of a Transcatheter Tricuspid Valve Annuloplasty: SCOUT Trial 30-Day Results.
Rebecca T. Hahn,Christopher Meduri,Charles J. Davidson,Scott Lim,Tamim Nazif,Mark J. Ricciardi,Vivek Rajagopal,Gorav Ailawadi,Mani A. Vannan,James D. Thomas,Dale E. Fowler,Stuart Rich,Randy Martin,Geraldine Ong,Adam Groothuis,Susheel Kodali +15 more
TL;DR: The 30-day results of the SCOUT trial confirmed the safety of the novel transcatheter device, which reduced TA and EROA, increased LVSV, and improved QoL.
Journal ArticleDOI
Strut Position, Blood Flow, and Drug Deposition Implications for Single and Overlapping Drug-Eluting Stents
Brinda Balakrishnan,Abraham R. Tzafriri,Philip Seifert,Adam Groothuis,Campbell Rogers,Elazer R. Edelman +5 more
TL;DR: Simulations that coupled strut configurations with flow dynamics correlated with in vivo effects and revealed that drug deposition occurs less via contact between drug coating and the arterial wall than via flow-mediated deposition of blood-solubilized drug.
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In vivo and in vitro tracking of erosion in biodegradable materials using non-invasive fluorescence imaging
Natalie Artzi,Natalie Artzi,Nuria Oliva,Cristina Puron,Sagi Shitreet,Shay Artzi,Adriana bon Ramos,Adam Groothuis,G. Gary Sahagian,Elazer R. Edelman,Elazer R. Edelman +10 more
TL;DR: In this article, the authors track the hydrolytic and enzymatic erosion of model materials by non-invasive fluorescence imaging, which allows the prediction of in vivo erosion from in vitro data.
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First-in-human transcatheter tricuspid valve repair in a patient with severely regurgitant tricuspid valve.
Joachim Schofer,Klaudija Bijuklic,Claudia Tiburtius,Lorenz Hansen,Adam Groothuis,Rebecca T. Hahn +5 more
TL;DR: Transcatheter tricuspid valve repair could become an effective treatment for high-surgical risk patients who are non-responsive to optimal medical therapy.