Adam Kepes

TL;DR: The induced synthesis of β-galactosidase in Escherichia coli has been studied initially after addition of the inducer and terminally after removal of theinducer, finding the inactivation of the repressor and the start of messenger RNA synthesis followed the addition of inducer without delay.

TL;DR: A model is proposed which is compatible with the observed behaviour of the entry and exit parameters under various conditions, and it is shown that the entry mechanism is catalytic; it is coupled with metabolic energy donors.

TL;DR: It is shown that lactose is not an inducer of the “Lac” operon in Escherichia coli K-12 and several compounds obtained by the action of galactosidase on a mixture of lactose and various alcohols have been isolated and shown to be inducers of the system.

TL;DR: The determination of the half-life of A coding capacity as the time constant of the decreasing rate of synthesis after a pulse indicates that the A part of the messenger can be inactivated independently from the Z part, thus accounting for the decreased molar yield of the A cistron product.

TL;DR: The residual enzyme-synthesizing ability under these conditions arises from the ability of preformed messenger to bind new ribosomes and to initiate and terminate new complete peptide chains, which decreases exponentially with time whereas process (b) has a linear time course.