A
Adam P. Carroll
Researcher at University of Newcastle
Publications - 18
Citations - 1367
Adam P. Carroll is an academic researcher from University of Newcastle. The author has contributed to research in topics: microRNA & Gene silencing. The author has an hindex of 13, co-authored 18 publications receiving 1257 citations. Previous affiliations of Adam P. Carroll include John Hunter Hospital.
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Journal ArticleDOI
Schizophrenia is associated with an increase in cortical microRNA biogenesis.
TL;DR: A significant schizophrenia-associated increase in global microRNA expression was associated with an elevation of primary microRNA processing and corresponded with an increase in the microprocessor component DGCR8.
Journal ArticleDOI
Dysregulation of miRNA 181b in the temporal cortex in schizophrenia
Natalie J. Beveridge,Paul A. Tooney,Adam P. Carroll,Erin Gardiner,Nikola A. Bowden,Rodney J. Scott,Nham Tran,Irina Dedova,Murray J. Cairns +8 more
TL;DR: Analysis of global microRNA expression in postmortem cortical grey matter from the superior temporal gyrus revealed significant up-regulation of miR-181b expression in schizophrenia.
Journal ArticleDOI
MicroRNAs miR-17 and miR-20a Inhibit T Cell Activation Genes and Are Under-Expressed in MS Whole Blood
Mathew B Cox,Murray J. Cairns,Kaushal S. Gandhi,Adam P. Carroll,Sophia M. Moscovis,Graeme J. Stewart,Simon Broadley,Rodney J. Scott,David R. Booth,Jeannette Lechner-Scott +9 more
TL;DR: It is demonstrated that these miRNAs modulate T cell activation genes in a knock-in and knock-down T cell model and also up-regulated in MS whole blood mRNA, suggesting these mi RNAs or their analogues may provide useful targets for new therapeutic approaches.
Journal ArticleDOI
Down-regulation of miR-17 family expression in response to retinoic acid induced neuronal differentiation.
Natalie J. Beveridge,Paul A. Tooney,Paul A. Tooney,Adam P. Carroll,Adam P. Carroll,Nham Tran,Nham Tran,Murray J. Cairns,Murray J. Cairns +8 more
TL;DR: Significantly, many of the target responses predicted by changes in miRNA expression were supported by the observed changes in gene expression, suggesting that the miR-17 family have an integral role in fine-tuning the pathways involved in the regulation of neuronal differentiation.
Journal ArticleDOI
Understanding principles of miRNA target recognition and function through integrated biological and bioinformatics approaches
TL;DR: There is a demand for the elegant design of future experiments such that principles of context‐specific miRNA target recognition and regulatory outcome can be accurately modeled in normal developmental and disease states.