M
Mathew B Cox
Researcher at University of Newcastle
Publications - 12
Citations - 1142
Mathew B Cox is an academic researcher from University of Newcastle. The author has contributed to research in topics: Single-nucleotide polymorphism & Transcriptome. The author has an hindex of 10, co-authored 12 publications receiving 1061 citations.
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Journal ArticleDOI
Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20
Melanie Bahlo,David R. Booth,Simon A. Broadley,Matthew A. Brown,Matthew A. Brown,Simon J. Foote,Lyn R. Griffiths,Trevor J. Kilpatrick,Trevor J. Kilpatrick,Jeanette Lechner-Scott,Pablo Moscato,Victoria M. Perreau,Justin P. Rubio,Rodney J. Scott,Rodney J. Scott,Jim Stankovich,Graeme J. Stewart,Bruce V. Taylor,James S. Wiley,Glynnis Clarke,Mathew B Cox,Peter A. Csurhes,Patrick Danoy,Karen E. Drysdale,Judith Field,Judith M. Greer,Preethi Guru,Johanna Hadler,Brendan J. McMorran,Cathy J Jensen,Laura J. Johnson,Ruth McCallum,Marilyn E. Merriman,Tony R. Merriman,Karen Pryce,Lotfi Tajouri,Ella J Wilkins,Brian L. Browning,Sharon R. Browning,D. I. Perera,Simon Broadley,Helmut Butzkueven,Helmut Butzkueven,William M. Carroll,Caron Chapman,Allan G. Kermode,Mark Marriott,Deborah F. Mason,Robert Heard,Michael P. Pender,Michael P. Pender,Mark Slee,Niall Tubridy,Ernest Willoughby +53 more
TL;DR: To identify multiple sclerosis (MS) susceptibility loci, a genome-wide association study in 1,618 cases and used shared data for 3,413 controls and observed a statistical interaction between SNPs in EVI5-RPL5 and HLA-DR15.
Journal ArticleDOI
MicroRNAs miR-17 and miR-20a Inhibit T Cell Activation Genes and Are Under-Expressed in MS Whole Blood
Mathew B Cox,Murray J. Cairns,Kaushal S. Gandhi,Adam P. Carroll,Sophia M. Moscovis,Graeme J. Stewart,Simon Broadley,Rodney J. Scott,David R. Booth,Jeannette Lechner-Scott +9 more
TL;DR: It is demonstrated that these miRNAs modulate T cell activation genes in a knock-in and knock-down T cell model and also up-regulated in MS whole blood mRNA, suggesting these mi RNAs or their analogues may provide useful targets for new therapeutic approaches.
Journal ArticleDOI
The multiple sclerosis whole blood mRNA transcriptome and genetic associations indicate dysregulation of specific T cell pathways in pathogenesis
Kaushal S. Gandhi,Fiona C. McKay,Mathew B Cox,Carlos Riveros,Nicola J. Armstrong,Robert Heard,Steve Vucic,David W. Williams,Jim Stankovich,Matthew A. Brown,Patrick Danoy,Graeme J. Stewart,Simon Broadley,Pablo Moscato,Jeannette Lechner-Scott,Rodney J. Scott,David R. Booth +16 more
TL;DR: Overall, data indicate dysregulation of T cells can be detected in the whole blood of untreated MS patients, and supports targeting of activated T cells in therapy for all forms of MS.
Journal ArticleDOI
IL12A, MPHOSPH9/CDK2AP1 and RGS1 are novel multiple sclerosis susceptibility loci
Federica Esposito,Nikolaos A. Patsopoulos,Sabine Cepok,Ingrid Kockum,Virpi M. Leppä,Virpi M. Leppä,David R. Booth,Robert Heard,Graeme J. Stewart,Mathew B Cox,Rodney J. Scott,Jeannette Lechner-Scott,An Goris,Rita Dobosi,Bénédicte Dubois,John D. Rioux,Annette Bang Oturai,Helle Bach Søndergaard,Finn Sellebjerg,Per Soelberg Sørensen,Mauri Reunanen,Keijo Koivisto,Isabelle Cournu-Rebeix,Isabelle Cournu-Rebeix,Isabelle Cournu-Rebeix,Bertrand Fontaine,Bertrand Fontaine,Bertrand Fontaine,Juliane Winkelmann,Christian Gieger,Carmen Infante-Duarte,Frauke Zipp,Laura Bergamaschi,Maurizio Leone,Roberto Bergamaschi,Paola Cavalla,Åslaug R. Lorentzen,Inger-Lise Mero,Elisabeth Gulowsen Celius,Hanne F. Harbo,Anne Spurkland,Manuel Comabella,B. Bryneda,Lars Alfredsson,Luisa Bernardinelli,Luisa Bernardinelli,Neil Robertson,Clive Hawkins,Lisa F. Barcellos,Gary W. Beecham,William S. Bush,Bruce A.C. Cree,Mark J. Daly,Adrian J. Ivinson,Cristin Aubin,Alastair Compston,Sandra D'Alfonso,Jonathan L. Haines,Stephen L. Hauser,B. Hemmer,Jan Hillert,Jacob L. McCauley,Jorge R. Oksenberg,Tomas Olsson,Aarno Palotie,Aarno Palotie,Leena Peltonen,Leena Peltonen,Leena Peltonen,Margaret A. Pericak-Vance,Janna Saarela,Janna Saarela,Stephen Sawcer,Barbara Elaine Stranger,Filippo Martinelli Boneschi,G. Comi,David A. Hafler,P. I. W. de Bakker,P. L. De Jager +78 more
TL;DR: Three new MS susceptibility loci are reported, including a novel inflammatory disease locus that could affect autoreactive cell proliferation and a meta-analysis across the replication collections and with the discovery data set were performed.
Journal ArticleDOI
Potential association of vitamin D receptor polymorphism Taq1 with multiple sclerosis.
Mathew B Cox,Maria Ban,Nikola A. Bowden,Amie Baker,Rodney J. Scott,Jeannette Lechner-Scott,Jeannette Lechner-Scott +6 more
TL;DR: There appears to be a relationship between polymorphisms in the VDR and the risk of MS, which is potentially modified by HLA-DRB1*1501.