Adam Spiro

TL;DR: The algorithm, which combined machine-learning and deep-learning approaches, can be applied to assess breast cancer at a level comparable to radiologists and has the potential to substantially reduce missed diagnoses of breast cancer.

TL;DR: This study inactivated the enzymes responsible for the demethylation reaction in the B-cell lineage and in this manner has shown that this epigenetic mark plays a critical role in development, independently of the many specific transcription factors that direct the selection of genes involved in cell differentiation.

TL;DR: In this article, the source neurons are modeled as non-stationary mixture-of-Gaussians and transition probabilities between candidate mixtures are computed, and a globally optimal clustering solution is found as the maximum a-posteriori solution of the resulting probabilistic model.

TL;DR: Reconstructed cell lineage trees of patients with acute myeloid leukemia showed that leukemia cells at relapse were shallow compared with cells at diagnosis and were closely related to their stem cell subpopulation, implying that in these instances relapse might have originated from rarely dividing stem cells.

TL;DR: Using genome-wide analysis, a postnatal pathway involving gender-specific demethylation that occurs exclusively in the male liver is discovered, and data show that the methylation state at these loci is associated with and appears to play a role in the transcriptional regulation of nearby genes.