H
Howard Cedar
Researcher at Hebrew University of Jerusalem
Publications - 161
Citations - 26363
Howard Cedar is an academic researcher from Hebrew University of Jerusalem. The author has contributed to research in topics: DNA methylation & Methylation. The author has an hindex of 79, co-authored 159 publications receiving 24958 citations. Previous affiliations of Howard Cedar include Laboratory of Molecular Biology.
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Journal ArticleDOI
Linking DNA methylation and histone modification: patterns and paradigms
Howard Cedar,Yehudit Bergman +1 more
TL;DR: Relationships between DNA methylation and histone modification have implications for understanding normal development as well as somatic cell reprogramming and tumorigenesis.
Journal ArticleDOI
Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer
Yeshayahu Schlesinger,Ravid Straussman,Ilana Keshet,Shlomit Farkash,Merav Hecht,Joseph Zimmerman,Eran Eden,Zohar Yakhini,Zohar Yakhini,Etti Ben-Shushan,Benjamin Reubinoff,Yehudit Bergman,Itamar Simon,Howard Cedar +13 more
TL;DR: Using chromatin immunoprecipitation analysis, this paper showed that genes methylated in cancer cells are specifically packaged with nucleosomes containing histone H3 trimethylated on Lys27.
Journal ArticleDOI
Allelic inactivation regulates olfactory receptor gene expression.
TL;DR: This model, involving inactivation of one allelic array and cis control of the active array, provides a mechanism such that individual neurons express one or a small number of receptors.
Journal ArticleDOI
DNA methylation and gene activity
TL;DR: The above experiments support a relatively simple model to explain the role of DNA methylation in vivo and provide a general mechanism for transcriptional repression which may operate independent of the requirement for interactions between cis-acting regulatory elements and tissue-specific factors.
Journal ArticleDOI
Sp1 elements protect a CpG island from de novo methylation
Michael Brandeis,David A. Frank,Ilana Keshet,Zahava Siegfried,M Mendelsohn,A Nemes,V Temper,Aharon Razin,Howard Cedar +8 more
TL;DR: It is shown that Spl elements play a key role in protecting a CpG island in the adenine phosphor!bosyItransferase (APRT) gene from de novo methylation, which represents a critical step in embryogenesis.