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Adela Straskova
Researcher at University of Defence
Publications - 11
Citations - 271
Adela Straskova is an academic researcher from University of Defence. The author has contributed to research in topics: Francisella tularensis & Virulence. The author has an hindex of 6, co-authored 11 publications receiving 241 citations. Previous affiliations of Adela Straskova include Swedish Defence Research Agency & Academy of Sciences of the Czech Republic.
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Journal ArticleDOI
Tetratricopeptide repeat motifs in the world of bacterial pathogens: role in virulence mechanisms.
Lukas Cerveny,Adela Straskova,Vera Dankova,Anetta Härtlova,Martina Ceckova,Frantisek Staud,Jiri Stulik +6 more
TL;DR: The current knowledge of the TPR-containing proteins involved in virulence mechanisms of bacterial pathogens are summarized while highlighting the importance of TPR motifs for the proper functioning of class II chaperones of a type III secretion system in the pathogenesis of Yersinia, Pseudomonas, and Shigella.
Journal ArticleDOI
Proteome analysis of an attenuated Francisella tularensis dsbA mutant: identification of potential DsbA substrate proteins.
Adela Straskova,Ivona Pavkova,Marek Link,Anna-Lena Forslund,Kerstin Kuoppa,Laila Noppa,M. Kroca,Alena Fučíková,Jana Klimentova,Zuzana Krocova,Åke Forsberg,Jiri Stulik +11 more
TL;DR: Using a combination of classical and shotgun proteome analyses, several proteins that accumulated in fractions enriched for membrane-associated proteins in the dsbA mutant are identified as substrate candidates for the DsbA disulfide oxidoreductase as well as being responsible for the virulence attenuation of the dSBA mutant.
Journal ArticleDOI
Deletion of IglH in virulent Francisella tularensis subsp. holarctica FSC200 strain results in attenuation and provides protection against the challenge with the parental strain.
Adela Straskova,Lukas Cerveny,Petra Spidlova,Vera Dankova,Davor Belčić,Marina Šantić,Jiri Stulik +6 more
TL;DR: It is shown that the iglH gene is necessary for intracellular growth and escape of F. tularensis from phagosomes and is avirulent in a mouse model of infection and persists in the organs for about three weeks after infection.
Journal ArticleDOI
Francisella tularensis subsp. holarctica DsbA homologue: a thioredoxin-like protein with chaperone function.
Monika Schmidt,Monika Schmidt,Jana Klimentova,Pavel Rehulka,Adela Straskova,Petra Spidlova,Barbora Szotáková,Jiri Stulik,Ivona Pavkova +8 more
TL;DR: Recombinant protein analysis revealed that the active site CXXC as well as the cis-proline residue and the FKBP_N domain are necessary for correct thiol/disulphide oxidoreductase activity.
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Francisella tularensis type B ΔdsbA mutant protects against type A strain and induces strong inflammatory cytokine and Th1-like antibody response in vivo.
Adela Straskova,Petra Spidlova,Sherry Mou,Patricia L. Worsham,Daniela Putzova,Ivona Pavkova,Jiri Stulik +6 more
TL;DR: Results show that vaccination with ΔdsbA/F SC200 mutant, but not ΔiglH/FSC200 mutants, induces an early innate inflammatory response leading to strong Th1-like antibody response, and elicited protection against the subsequent challenge with type A SCHU S4 strain in mice.