L
Lukas Cerveny
Researcher at Charles University in Prague
Publications - 45
Citations - 1371
Lukas Cerveny is an academic researcher from Charles University in Prague. The author has contributed to research in topics: Placenta & Efflux. The author has an hindex of 18, co-authored 43 publications receiving 1154 citations. Previous affiliations of Lukas Cerveny include Central Manchester University Hospitals NHS Foundation Trust & University of Defence.
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Journal ArticleDOI
Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways.
Lukas Cerveny,Lucie Svecova,Eva Anzenbacherová,Radim Vrzal,Frantisek Staud,Zdenek Dvorak,Jitka Ulrichová,Pavel Anzenbacher,Petr Pavek +8 more
TL;DR: The results demonstrate that VPA has potential to up-regulate CYP3A4 and MDR1 through direct activation of CAR and/or PXR pathways and suggest that Vpa synergistically augments the effect of rifampicin in transactivation of CYP 3A4 in primary human hepatocytes.
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Tetratricopeptide repeat motifs in the world of bacterial pathogens: role in virulence mechanisms.
Lukas Cerveny,Adela Straskova,Vera Dankova,Anetta Härtlova,Martina Ceckova,Frantisek Staud,Jiri Stulik +6 more
TL;DR: The current knowledge of the TPR-containing proteins involved in virulence mechanisms of bacterial pathogens are summarized while highlighting the importance of TPR motifs for the proper functioning of class II chaperones of a type III secretion system in the pathogenesis of Yersinia, Pseudomonas, and Shigella.
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Pharmacotherapy in pregnancy; effect of ABC and SLC transporters on drug transport across the placenta and fetal drug exposure.
TL;DR: Functional expression of placental drug transporters in the trophoblast and the possibility of drug–drug interactions must be considered to optimize pharmacotherapy during pregnancy.
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Examination of Glucocorticoid Receptor α-Mediated Transcriptional Regulation of P-glycoprotein, CYP3A4, and CYP2C9 Genes in Placental Trophoblast Cell Lines
Petr Pavek,Lukas Cerveny,Lucie Svecova,M. Brysch,Antonin Libra,Radim Vrzal,Petr Nachtigal,Frantisek Staud,Jitka Ulrichová,Z. Fendrich,Zdenek Dvorak +10 more
TL;DR: It is concluded that GRalpha may be involved in the transcriptional regulation of P-glycoprotein in the placental trophoblast, and the CYP3A4 and CYP2C9 genes are not inducible through GRalpha in placental cell lines, due to the lack of HNF4alpha expression and possibly some additional hepatocyte-specific transcriptional factors.
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Interactions of tenofovir and tenofovir disoproxil fumarate with drug efflux transporters ABCB1, ABCG2, and ABCC2; role in transport across the placenta.
TL;DR: While placental transport of TFV is restricted passively, by physical-chemical properties of the molecule, mother-to-fetus passage of TDF is actively hindered by placental ABCB1 and ABCG2 transporters, pumping this compound from trophoblast back to maternal circulation.