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Adolfo J. de Bold
Researcher at University of Ottawa
Publications - 59
Citations - 3267
Adolfo J. de Bold is an academic researcher from University of Ottawa. The author has contributed to research in topics: Brain natriuretic peptide & Natriuretic peptide. The author has an hindex of 28, co-authored 58 publications receiving 3018 citations. Previous affiliations of Adolfo J. de Bold include Kingston General Hospital & Hotel Dieu Hospital.
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The amino acid sequence of an atrial peptide with potent diuretic and natriuretic properties
TL;DR: A 28 amino acid peptide with diuretic and natriuretic activity has been purified from rat atrial muscle and is identical to that of atrial natriUREtic factor and cardionatrin I isolated fromRat atria.
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The endocrine function of the heart
TL;DR: The elevation of circulating ANF and BNP in heart failure or following acute coronary syndromes has been shown to have diagnostic and prognostic implications, and these peptides themselves hold promise as therapeutic agents in the treatment of heart failure.
Journal ArticleDOI
Selective upregulation of cardiac brain natriuretic peptide at the transcriptional and translational levels by pro-inflammatory cytokines and by conditioned medium derived from mixed lymphocyte reactions via p38 MAP kinase.
TL;DR: Investigations show that exposure of cultured rat cardiocytes to specific pro-inflammatory cytokines as well as MLR-CM results in the only known instance of upregulation of cardiac BNP at the transcriptional and translational levels without a corresponding increase in ANF gene expression.
Journal ArticleDOI
Cardiac natriuretic peptides
Jens P. Goetze,Benoit G. Bruneau,Benoit G. Bruneau,Hugo R. Ramos,Tsuneo Ogawa,Mercedes Kuroski de Bold,Adolfo J. de Bold +6 more
TL;DR: The physiological regulation and actions of the cardiac natriuretic peptides and their clinical use as powerful diagnostic and prognostic biomarkers of heart disease are discussed.
Journal ArticleDOI
The physiological and pathophysiological modulation of the endocrine function of the heart.
Adolfo J. de Bold,Kenneth K.-Y. Ma,Ying Zhang,Mercedes L. Kuroski de Bold,Michael Bensimon,Ali Khoshbaten +5 more
TL;DR: The finding that circulating levels of BNP are selectively increased before and during overt cardiac allograft rejection episodes in human patients suggests that enhanced BNP plasma levels could form a basis for a noninvasive test for cardiac allogsraft rejection.