Journal ArticleDOI
The amino acid sequence of an atrial peptide with potent diuretic and natriuretic properties
TLDR
A 28 amino acid peptide with diuretic and natriuretic activity has been purified from rat atrial muscle and is identical to that of atrial natriUREtic factor and cardionatrin I isolated fromRat atria.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 1983-12-28. It has received 740 citations till now. The article focuses on the topics: Alpha-Atrial Natriuretic Peptide & NPR2.read more
Citations
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Journal ArticleDOI
Atrial natriuretic factor—a circulating hormone stimulated by volume loading
TL;DR: A sensitive and specific radio-immunoassay for atrial natriuretic factor and its stimulation on volume loading is described and its effects on salt loading and blood volume are described.
Journal ArticleDOI
Natriuretic peptides, their receptors, and cyclic guanosine monophosphate-dependent signaling functions.
TL;DR: The structure, function, regulation, and biological consequences of natriuretic peptides and their associated signaling proteins are described.
Journal ArticleDOI
Atrial natriuretic factor: a hormone produced by the heart
TL;DR: This hormone, described in 1981 as atrial natriuretic factor (ANF), is diuretic, hypotensive, and has an inhibitory effect on renin and aldosterone secretion.
Journal ArticleDOI
Atrial Natriuretic Peptide Elevation in Congestive Heart Failure in the Human
John C. Burnett,P. C. Kao,DC Hu,D.W. Heser,D Heublein,Joey P. Granger,T. J. Opgenorth,GS Reeder +7 more
TL;DR: It is established that elevated cardiac filling pressure is associated with increased circulating concentrations of atrial natriuretic peptide and that congestive heart failure is not characterized by a deficiency in atrialNatriureic peptide, but with its elevation.
Journal ArticleDOI
The Heart and the Atrial Natriuretic Factor
Marc Cantin,Jacques Genest +1 more
TL;DR: The search for natriuretic hormones or factors by studies of negative pressure breathing, atrial distension experiments, head-out water immersion, expansion of blood volume, Na+/K+-ATPase inhibitors and parabiosis experiments in Dahl rats has led to the finding that the atria are a peptide-secreting endocrine gland.
References
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Journal ArticleDOI
A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats
A. J. De Bold,A. J. De Bold,H.B. Borenstein,H.B. Borenstein,A. T. Veress,A. T. Veress,H. Sonnenberg,H. Sonnenberg +7 more
TL;DR: It is concluded that the atrial extract contained an extremely powerful inhibitor of renal tubular NaCl re absorption, which caused a rapid, more than 30-fold increase of sodium and chloride excretions, while urine volume and potassium excretion doubled.
Journal ArticleDOI
Bioactive cardiac substances: potent vasorelaxant activity in mammalian atria.
Mark G. Currie,David M. Geller,Barbara R. Cole,John G. Boylan,Wu YuSheng,Sandra W. Holmberg,Philip Needleman +6 more
TL;DR: It appears that atria possess at least two peptides that elicit smooth muscle relaxation and natriuresis, suggesting an endogenous system of fluid volume regulation.
Journal ArticleDOI
Specific granules in atrial muscle cells.
TL;DR: Atrial granules are larger and more numerous in smaller species (rat, mouse), and generally smaller and less numerous in larger mammals (dog, cat, human); they are absent from the atrial fibers of very young fetuses but are present in those of newborn animals.
Journal ArticleDOI
Intrarenal localization of the natriuretic effect of cardiac atrial extract.
TL;DR: In anesthetized rats micropuncture and microcatheterization were used to collect tubular fluid from end proximal and distal tubules and from the outer medullary collecting duct, and sodium excretion increased 17-fold after atrial extract, significantly greater rise than the 3-fold increase after ventricular extract.
Journal ArticleDOI
Micropuncture studies of the renal effects of atrial natriuretic substance
TL;DR: The data suggest that to a major extent the natriuresis is caused by transport inhibition along collecting tubules and collecting ducts and at high doses a rise in filtration rate contributes to theNatriuretic effect of atrial extracts.
Related Papers (5)
Purification and complete amino acid sequence of α-human atrial natriuretic polypeptide (α-hANP)
Kenji Kangawa,Hisayuki Matsuo +1 more