A
Adrian Cohen
Researcher at Radboud University Nijmegen
Publications - 6
Citations - 1306
Adrian Cohen is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Histone & Histone H3. The author has an hindex of 6, co-authored 6 publications receiving 1228 citations. Previous affiliations of Adrian Cohen include University of Southern Denmark.
Papers
More filters
Journal ArticleDOI
MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties.
Xavier Le Guezennec,Michiel Vermeulen,Arie B. Brinkman,Wieteke A. M. Hoeijmakers,Adrian Cohen,Edwin Lasonder,Hendrik G. Stunnenberg +6 more
TL;DR: Ch Chromatin immunoprecipitation experiments revealed that PRMT5 and MBD2 are recruited to CpG islands in a methylation-dependent manner in vivo and that H4R3, a substrate of PRMT, is methylated at these loci.
Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genes This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits distribution, and reproduction in any medium, provided the original author and source are credited. This license does not permit commercial exploitation or the creation of derivative works without specific permission.
Maxim Nekrasov,Tetyana Klymenko,Sven Fraterman,Bernadett Papp,Katarzyna Oktaba,Adrian Cohen,Hendrik G. Stunnenberg,Matthias Wilm,Jürg Müller +8 more
TL;DR: Analysis of Drosophila mutants that lack Pcl unexpectedly reveals that Pcl‐PRC2 is required to generate high levels of H3‐K27 trimethylation at Polycomb target genes but is dispensable for the genome‐wide H3-K27 mono‐ and dimethylation that is generated by PRC2.
Journal ArticleDOI
Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genes
Maxim Nekrasov,Tetyana Klymenko,Sven Fraterman,Bernadett Papp,Katarzyna Oktaba,Thomas Köcher,Adrian Cohen,Hendrik G. Stunnenberg,Matthias Wilm,Jürg Müller +9 more
TL;DR: In this article, the biochemical purification and characterization of a distinct form of Drosophila PRC2 that contains the Polycomb group protein polycomblike (Pcl).
Journal ArticleDOI
Dynamic histone H3 epigenome marking during the intraerythrocytic cycle of Plasmodium falciparum.
Adriana M. Salcedo-Amaya,Marc A. van Driel,Blaise T. F. Alako,Morten Beck Trelle,Antonia van den Elzen,Adrian Cohen,Eva M. Janssen-Megens,Marga van de Vegte-Bolmer,Rebecca R. Selzer,A. Leonardo Iniguez,Roland Green,Robert W. Sauerwein,Ole N. Jensen,Hendrik G. Stunnenberg +13 more
TL;DR: An unforeseen and unique plasticity in the use of the epigenetic marks is revealed and implies the presence of distinct epigenetic pathways in gene silencing/activation throughout the erythrocytic cycle.
Journal ArticleDOI
Global Histone Analysis by Mass Spectrometry Reveals a High Content of Acetylated Lysine Residues in the Malaria Parasite Plasmodium falciparum
Morten Beck Trelle,Adriana M. Salcedo-Amaya,Adrian Cohen,Hendrik G. Stunnenberg,Ole N. Jensen +4 more
TL;DR: A first comprehensive map of histone modifications in P. falciparum and the utility of tandem MS for detailed analysis of peptides containing multiple PTMs is highlighted, providing a comprehensive view of epigenetic marks in the parasite.