M
Marga van de Vegte-Bolmer
Researcher at Radboud University Nijmegen
Publications - 69
Citations - 4341
Marga van de Vegte-Bolmer is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Plasmodium falciparum & Gametocyte. The author has an hindex of 35, co-authored 69 publications receiving 3668 citations. Previous affiliations of Marga van de Vegte-Bolmer include Radboud University Nijmegen Medical Centre.
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Journal ArticleDOI
Protection against a Malaria Challenge by Sporozoite Inoculation
Meta Roestenberg,Matthew B. B. McCall,Joost Hopman,Jorien Wiersma,Adrian J. F. Luty,Geert-Jan van Gemert,Marga van de Vegte-Bolmer,Ben C. L. van Schaijk,Karina Teelen,Theo Arens,Lopke Spaarman,Quirijn de Mast,Will Roeffen,Georges Snounou,Laurent Rénia,André J. A. M. van der Ven,Cornelus C. Hermsen,Robert W. Sauerwein +17 more
TL;DR: The induction of parasite-specific pluripotent effector memory T cells producing interferon-gamma, tumor necrosis factor alpha, and interleukin-2 as a promising immunologic marker of protection against a homologous malaria challenge can be induced by the inoculation of intact sporozoites.
Journal ArticleDOI
Submicroscopic Plasmodium falciparum gametocyte densities frequently result in mosquito infection.
Petra Schneider,J. Teun Bousema,Louis Clément Gouagna,Silas Otieno,Marga van de Vegte-Bolmer,Sabah A. Omar,Robert W. Sauerwein +6 more
TL;DR: The results show that transmission occurs efficiently at sub microscopic gametocyte densities and that carriers harboring submicroscopicgametocytemia constitute a considerable proportion of the human infectious reservoir.
Journal ArticleDOI
Long-term protection against malaria after experimental sporozoite inoculation: an open-label follow-up study
Meta Roestenberg,Anne C. Teirlinck,Matthew B. B. McCall,Karina Teelen,Krystelle Nganou Makamdop,Jorien Wiersma,Theo Arens,Pieter Beckers,Geert-Jan van Gemert,Marga van de Vegte-Bolmer,André J. A. M. van der Ven,Adrian J. F. Luty,Cornelus C. Hermsen,Robert W. Sauerwein +13 more
TL;DR: Artificially induced immunity lasts longer than generally recorded after natural exposure; providing a new avenue of research into the mechanisms of malaria immunity.
Journal ArticleDOI
Dynamic histone H3 epigenome marking during the intraerythrocytic cycle of Plasmodium falciparum.
Adriana M. Salcedo-Amaya,Marc A. van Driel,Blaise T. F. Alako,Morten Beck Trelle,Antonia van den Elzen,Adrian Cohen,Eva M. Janssen-Megens,Marga van de Vegte-Bolmer,Rebecca R. Selzer,A. Leonardo Iniguez,Roland Green,Robert W. Sauerwein,Ole N. Jensen,Hendrik G. Stunnenberg +13 more
TL;DR: An unforeseen and unique plasticity in the use of the epigenetic marks is revealed and implies the presence of distinct epigenetic pathways in gene silencing/activation throughout the erythrocytic cycle.
Journal ArticleDOI
Protection against malaria after immunization by chloroquine prophylaxis and sporozoites is mediated by preerythrocytic immunity
Else M. Bijker,Guido J. H. Bastiaens,Anne C. Teirlinck,Geert-Jan van Gemert,Wouter Graumans,Marga van de Vegte-Bolmer,Rianne Siebelink-Stoter,Theo Arens,Karina Teelen,Wiebke Nahrendorf,Edmond J. Remarque,Will Roeffen,Annemieke Jansens,Dunja Zimmerman,Martijn W. Vos,Ben C. L. van Schaijk,Jorien Wiersma,André J. A. M. van der Ven,Quirijn de Mast,Lisette van Lieshout,Jaco J. Verweij,Cornelus C. Hermsen,Anja Scholzen,Robert W. Sauerwein +23 more
TL;DR: The complete lack of protection against blood-stage challenge indicates that CPS-induced protection is mediated by immunity against preerythrocytic stages, however, evidence is presented for immune recognition of P. falciparum-infected erythroCytes, suggesting memory responses unable to generate functional immunity.