A
Adrian Egli
Researcher at University Hospital of Basel
Publications - 287
Citations - 6349
Adrian Egli is an academic researcher from University Hospital of Basel. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 32, co-authored 236 publications receiving 4567 citations. Previous affiliations of Adrian Egli include University of Alberta & University of Basel.
Papers
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Journal ArticleDOI
Prevalence of polyomavirus BK and JC infection and replication in 400 healthy blood donors.
Adrian Egli,Laura Infanti,Alexis Dumoulin,Andreas Buser,Jacqueline Samaridis,Christine Stebler,Rainer Gosert,Hans H. Hirsch,Hans H. Hirsch +8 more
TL;DR: This study provides important data about polyomavirus infection and replication in healthy, immunocompetent individuals and indicates significant differences between BKV and JCV with respect to virus-host interaction and epidemiology.
Journal ArticleDOI
Polyomavirus BK with rearranged noncoding control region emerge in vivo in renal transplant patients and increase viral replication and cytopathology.
Rainer Gosert,Christine Hanssen Rinaldo,Georg A. Funk,Adrian Egli,Emilio Ramos,Cinthia B. Drachenberg,Hans H. Hirsch,Hans H. Hirsch +7 more
TL;DR: In this paper, BKV noncoding control regions (NCCR), which coordinate viral gene expression and replication, were examined in kidney transplant patients with BK viremia and polyomavirus BK-associated nephropathy.
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Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells
Michal A. Stanczak,Shoib S. Siddiqui,Marcel P. Trefny,Daniela S. Thommen,Kayluz Frias Boligan,Stephan von Gunten,Alexandar Tzankov,Lothar Tietze,Didier Lardinois,Viola Heinzelmann-Schwarz,Michael von Bergwelt-Baildon,Wu Zhang,Heinz-Josef Lenz,Younghan Han,Christopher I. Amos,Mohammedyaseen Syedbasha,Adrian Egli,Frank Stenner,Daniel E. Speiser,Ajit Varki,Alfred Zippelius,Heinz Läubli +21 more
TL;DR: This work shows an upregulation of Siglecs, including Siglec-9, on tumor-infiltrating T cells from non–small cell lung cancer, colorectal, and ovarian cancer patients and identifies the sialoglycan-SAMP/Siglec pathway as a potential target for improving T cell activation for immunotherapy.
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Polyomavirus BK-specific cellular immune response to VP1 and large T-antigen in kidney transplant recipients.
S. Binggeli,Adrian Egli,Stefan Schaub,Isabelle Binet,Michael Mayr,Jürg Steiger,Hans H. Hirsch,Hans H. Hirsch +7 more
TL;DR: Control of BkV replication is correlated with differentiated expansion of BKV‐specific cellular immune responses, and responses to interferon‐γ and VP1‐specific IFN‐γ were higher and more likely to involve CD4+ T cells, while CD8- T cells were more frequently directed against LT.
Journal ArticleDOI
Gut microbiota modulate T cell trafficking into human colorectal cancer
Eleonora Cremonesi,Valeria Governa,Jesus Francisco Glaus Garzon,Valentina Mele,Francesca Amicarella,Manuele G. Muraro,Emanuele Trella,Virginie Galati-Fournier,Daniel Oertli,Silvio Däster,Raoul A. Droeser,Benjamin Weixler,Martin Bolli,Raffaele Rosso,Ulrich Nitsche,Nina Khanna,Adrian Egli,Simone Keck,Julia Slotta-Huspenina,Luigi Terracciano,Paul Zajac,Giulio C. Spagnoli,Serenella Eppenberger-Castori,Klaus-Peter Janssen,Lubor Borsig,Giandomenica Iezzi +25 more
TL;DR: Gut microbiota stimulate chemokine production by CRC cells, thus favouring recruitment of beneficial T cells into tumour tissues, and abundance of defined bacteria correlated with high Chemokine expression, enhanced T cell infiltration and improved survival.