T
Todd C. Skaar
Researcher at Indiana University
Publications - 258
Citations - 12853
Todd C. Skaar is an academic researcher from Indiana University. The author has contributed to research in topics: Tamoxifen & Gene. The author has an hindex of 48, co-authored 235 publications receiving 11197 citations. Previous affiliations of Todd C. Skaar include Indiana University – Purdue University Indianapolis & Georgetown University.
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CYP2D6 Genotype, Antidepressant Use, and Tamoxifen Metabolism During Adjuvant Breast Cancer Treatment
Y. Jin,Zeruesenay Desta,Vered Stearns,Bryan A. Ward,Herbert Ho,K. Lee,Todd C. Skaar,Anna Maria Storniolo,Lang Li,Adjei Araba,Rebecca L. Blanchard,Anne Nguyen,Lynda Ullmer,Jill Hayden,Suzanne Lemler,Richard M. Weinshilboum,James M. Rae,Daniel F. Hayes,David A. Flockhart +18 more
TL;DR: Interactions between CYP2D6 polymorphisms and coadministered antidepressants and other drugs that are CYP 2D6 inhibitors may be associated with altered tamoxifen activity.
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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors
JK Hicks,Jeffrey R. Bishop,Katrin Sangkuhl,Daniel J. Müller,Yuan Ji,SG Leckband,J. S. Leeder,Rebecca L. Graham,DL Chiulli,Adrián LLerena,Todd C. Skaar,Stuart A. Scott,Julia C. Stingl,Teri E. Klein,Kelly E. Caudle,Andrea Gaedigk +15 more
TL;DR: Evidence from the published literature supporting associations between CYP2D6 and CYC19 polymorphisms and SSRIs efficacy and safety is summarized and dosing recommendations for fluvoxamine, paroxetine, citalopram, escitaloprams, and sertraline based on CYP1C19 genotype are provided.
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Clinical Pharmacogenetics Implementation Consortium Guidelines for Cytochrome P450 2D6 Genotype and Codeine Therapy: 2014 Update
Kristine R. Crews,Andrea Gaedigk,Andrea Gaedigk,Henry M. Dunnenberger,J. S. Leeder,J. S. Leeder,Teri E. Klein,Kelly E. Caudle,Cyrine E. Haidar,Danny D. Shen,J T Callaghan,J T Callaghan,Senthilkumar Sadhasivam,Cynthia A. Prows,Evan D. Kharasch,Todd C. Skaar +15 more
TL;DR: This document is an update to the 2012 Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for CYP2D6 genotype and codeine therapy and provides therapeutic recommendations for codeine based on CYP1D8 genotype.
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Antiestrogen resistance in breast cancer and the role of estrogen receptor signaling
Robert Clarke,Minetta C. Liu,Kerrie B. Bouker,Zhiping Gu,Richard Y. Lee,Yuelin Zhu,Todd C. Skaar,Bianca P. Gomez,Kerry A. O’Brien,Yue Wang,Leena Hilakivi-Clarke +10 more
TL;DR: A gene network approach to exploring the mechanistic aspects of antiestrogen resistance is proposed using transcriptome and proteome analyses, and candidate genes are begun to identify that comprise one component of a larger, putative gene network.
Journal ArticleDOI
Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: implication for optimization of breast cancer treatment.
S. Borges,Zeruesenay Desta,Lang Li,Todd C. Skaar,Bryan A. Ward,Anne Nguyen,Y. Jin,Anna Maria Storniolo,D. Michele Nikoloff,Lin Wu,Grant Hillman,Daniel F. Hayes,Vered Stearns,David A. Flockhart +13 more
TL;DR: A prospective trial in 158 patients with breast cancer who were taking tamoxifen to further understand the effect of CYP2D6 genotype and concomitant medications on endoxifens plasma concentrations.