A
Agata Fernández-Gamba
Researcher at Fundación Instituto Leloir
Publications - 4
Citations - 176
Agata Fernández-Gamba is an academic researcher from Fundación Instituto Leloir. The author has contributed to research in topics: Phosphorylation & Circadian rhythm. The author has an hindex of 4, co-authored 4 publications receiving 163 citations.
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Insulin-degrading enzyme: structure-function relationship and its possible roles in health and disease
TL;DR: The recently solved crystal structures of an inactive IDE mutant bound to four different substrates indicate, in accordance with previous compelling biochemical data, that peptide backbone conformation and size are major determinants of IDE recognition and substrate selectivity.
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Mmp1 processing of the PDF neuropeptide regulates circadian structural plasticity of pacemaker neurons.
Ana Depetris-Chauvin,Agata Fernández-Gamba,E. Axel Gorostiza,Anastasia Herrero,Eduardo M. Castaño,M. Fernanda Ceriani +5 more
TL;DR: Evidence is provided that PDF along with matrix metalloproteinases (Mmp1 and 2) are key in the control of circadian structural remodeling and circadian behavior, and in vitro analysis demonstrated that PDF is hydrolyzed by Mmp1, thereby suggesting that MMP1 could directly terminate its biological activity.
Journal ArticleDOI
Collapsin response mediator protein-2 phosphorylation promotes the reversible retraction of oligodendrocyte processes in response to non-lethal oxidative stress
Agata Fernández-Gamba,Maria Celeste Leal,Chera L. Maarouf,Christiane Richter-Landsberg,Terence Wu,Laura Morelli,Alex E. Roher,Eduardo M. Castaño +7 more
TL;DR: In this article, a non-lethal oxidative stress induced by 3-nitropropionic acid (3-NP) elicited a rapid shortening of processes in primary OLGs and in oligodendroglial cell line (OLN-93) cells.
Journal ArticleDOI
Amyloid peptides ABri and ADan show differential neurotoxicity in transgenic Drosophila models of familial British and Danish dementia.
María Silvina Marcora,María Silvina Marcora,Agata Fernández-Gamba,Luz A Avendaño,Cecilia Rotondaro,Osvaldo L. Podhajcer,Osvaldo L. Podhajcer,Ruben Vidal,Laura Morelli,Laura Morelli,María Fernanda Ceriani,María Fernanda Ceriani,Eduardo M Castaño,Eduardo M Castaño +13 more
TL;DR: The results support the differential neurotoxicity of ADan and ABri in the Drosophila eye and CNS at low expression levels and allow a systematic and unambiguous comparison of differences and similarities in the mechanisms of toxicity of diverse amyloid peptides associated with dementia.