Maria Celeste Leal

TL;DR: The results reinforce the relevance of functional IDE in the catabolism of extracellular Abeta by demonstrating that proteolytically-active plasma membrane associated-IDE is routed in living N2a cells to multivesicular bodies and subsequently, a major fraction is sorted to exosomes.

TL;DR: The recently solved crystal structures of an inactive IDE mutant bound to four different substrates indicate, in accordance with previous compelling biochemical data, that peptide backbone conformation and size are major determinants of IDE recognition and substrate selectivity.

TL;DR: It is proposed that in Tg2576 mice and in contrast to its behavior in Alzheimer brains, active IDE increases with age around plaques as a component of astrocyte activation as a result of A&bgr;-triggered inflammation.

TL;DR: The experiments suggest that WM activities become globally impaired during the course of AD with significant morphological, biochemical and functional consequential implications for gray matter function and cognitive deficits.

TL;DR: The results support the notion that optimal substrate degradation by IDE may require its association with organized-DRMs, and the concept that mis-location of Aβ degrading proteases away from DRMs may impair the physiological turn-over of A β in vivo deserves further investigation.