A
Agnieszka E. Gorska
Researcher at Vanderbilt University
Publications - 47
Citations - 6426
Agnieszka E. Gorska is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Transforming growth factor & Transforming growth factor beta. The author has an hindex of 29, co-authored 45 publications receiving 5927 citations. Previous affiliations of Agnieszka E. Gorska include Vanderbilt University Medical Center.
Papers
More filters
Journal ArticleDOI
TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia
Neil A. Bhowmick,Anna Chytil,David Plieth,Agnieszka E. Gorska,Nancy Dumont,Scott B. Shappell,M. Kay Washington,Eric G. Neilson,Harold L. Moses +8 more
TL;DR: TGF-β signaling in fibroblasts modulates the growth and oncogenic potential of adjacent epithelia in selected tissues and is associated with intraepithelial neoplasia in prostate and invasive squamous cell carcinoma of the forestomach.
Journal ArticleDOI
Abrogation of TGFβ signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis
Li Yang,Jianhua Huang,Xiubao Ren,Agnieszka E. Gorska,Anna Chytil,Mary Aakre,David P. Carbone,Lynn M. Matrisian,Ann Richmond,P. Charles Lin,Harold L. Moses +10 more
TL;DR: It is demonstrated that Gr-1+CD11b+ myeloid cells are recruited into mammary carcinomas with type II TGF beta receptor gene (Tgfbr2) deletion and directly promote tumor metastasis.
Journal ArticleDOI
Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-β signaling in cooperation with active Kras expression
Hideaki Ijichi,Anna Chytil,Agnieszka E. Gorska,Mary Aakre,Yoshio Fujitani,Shuko Fujitani,Christopher V.E. Wright,Harold L. Moses +7 more
TL;DR: The data show that blockade of TGF-beta signaling and activated Ras signaling cooperate to promote PDAC progression, which indicated a haploinsufficiency of T GF- beta signaling in this genetic context.
Journal ArticleDOI
Gr-1+CD11b+ Myeloid Cells Tip the Balance of Immune Protection to Tumor Promotion in the Premetastatic Lung
Hannah Yan,Michael W. Pickup,Yanli Pang,Agnieszka E. Gorska,Zhaoyang Li,Anna Chytil,Yipeng Geng,Jerome W. Gray,Harold L. Moses,Li Yang +9 more
TL;DR: Inhibition of Gr-1+CD11b+ cells could normalize the premetastatic lung environment, improve host immunosurveillance, and inhibit tumor metastasis.
Journal ArticleDOI
Mammary tumor suppression by transforming growth factor beta 1 transgene expression
D. F. Pierce,Agnieszka E. Gorska,Anna Chytil,Katherine S. Meise,David L. Page,Robert J. Coffey,Harold L. Moses +6 more
TL;DR: It is demonstrated that overexpression of TGF-alpha 1 in vivo can markedly suppress mammary tumor development and that MMTV-TGF-beta 1 transgenic mice are resistant to 7,12-dimethylbenz[a]anthracene-induced mammary tumors.