S
Scott B. Shappell
Researcher at Vanderbilt University Medical Center
Publications - 67
Citations - 6027
Scott B. Shappell is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Prostate cancer & Cancer. The author has an hindex of 38, co-authored 67 publications receiving 5817 citations. Previous affiliations of Scott B. Shappell include Baylor College of Medicine & University of Alabama at Birmingham.
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Journal ArticleDOI
TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia
Neil A. Bhowmick,Anna Chytil,David Plieth,Agnieszka E. Gorska,Nancy Dumont,Scott B. Shappell,M. Kay Washington,Eric G. Neilson,Harold L. Moses +8 more
TL;DR: TGF-β signaling in fibroblasts modulates the growth and oncogenic potential of adjacent epithelia in selected tissues and is associated with intraepithelial neoplasia in prostate and invasive squamous cell carcinoma of the forestomach.
Journal ArticleDOI
Prostate Pathology of Genetically Engineered Mice: Definitions and Classification. The Consensus Report from the Bar Harbor Meeting of the Mouse Models of Human Cancer Consortium Prostate Pathology Committee
Scott B. Shappell,George Thomas,Richard L. Roberts,Ron Herbert,Michael Ittmann,Mark A. Rubin,Peter A. Humphrey,John P. Sundberg,Nora Rozengurt,Roberto Barrios,Jerrold M. Ward,Robert D. Cardiff +11 more
TL;DR: It is recommended that investigators use the Bar Harbor Classification system when characterizing new GEM models or when conducting experimental interventions that may alter the phenotype or natural history of lesion progression in existing models.
Journal ArticleDOI
Clinical under staging of high risk nonmuscle invasive urothelial carcinoma treated with radical cystectomy
Sajal C. Dutta,Joseph A. Smith,Scott B. Shappell,Christopher S. Coffey,Sam S. Chang,Michael S. Cookson +5 more
TL;DR: In clinical and pathological, superficial stages T1 or less cases disease-free survival was excellent and selection of high risk superficial transitional cell carcinoma cases for continued bladder sparing treatment should include uninvolved muscle on biopsy and absent radiographic suspicion of invasion.
Journal Article
15S-Hydroxyeicosatetraenoic Acid Activates Peroxisome Proliferator-activated Receptor γ and Inhibits Proliferation in PC3 Prostate Carcinoma Cells
Scott B. Shappell,Rajnish A. Gupta,Suzanne Manning,Robert H. Whitehead,William E. Boeglin,Claus Schneider,Tom Case,James O. Price,Gregory S. Jack,Thomas M. Wheeler,Robert J. Matusik,Alan R. Brash,Raymond N. DuBois +12 more
TL;DR: The hypothesis that 15- LOX-2-derived 15S-HETE may constitute an endogenous ligand for PPARgamma in the prostate is supported and that loss of this pathway by reduced expression of 15-LOX- 2 may contribute to increased proliferation and reduced differentiation in prostate carcinoma.
Journal Article
A probasin-large T antigen transgenic mouse line develops prostate adenocarcinoma and neuroendocrine carcinoma with metastatic potential.
Naoya Masumori,Tania Z. Thomas,Pierre Chaurand,Tom Case,Manik Paul,Susan Kasper,Richard M. Caprioli,Taiji Tsukamoto,Scott B. Shappell,Robert J. Matusik +9 more
TL;DR: In the 12T-10 large probasin promoter-Tag mouse, high-grade prostatic intraepithelial neoplasia develops progressively greater NE differentiation and progresses to invasive adenocarcinoma and NE carcinoma, with a high percentage of metastases.