M
M. Kay Washington
Researcher at Vanderbilt University Medical Center
Publications - 163
Citations - 13222
M. Kay Washington is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Colitis & Inflammation. The author has an hindex of 52, co-authored 155 publications receiving 11478 citations. Previous affiliations of M. Kay Washington include Vanderbilt University.
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Journal ArticleDOI
TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia
Neil A. Bhowmick,Anna Chytil,David Plieth,Agnieszka E. Gorska,Nancy Dumont,Scott B. Shappell,M. Kay Washington,Eric G. Neilson,Harold L. Moses +8 more
TL;DR: TGF-β signaling in fibroblasts modulates the growth and oncogenic potential of adjacent epithelia in selected tissues and is associated with intraepithelial neoplasia in prostate and invasive squamous cell carcinoma of the forestomach.
Journal ArticleDOI
Soluble proteins produced by probiotic bacteria regulate intestinal epithelial cell survival and growth.
Fang Yan,Hanwei Cao,Timothy L. Cover,Timothy L. Cover,Robert H. Whitehead,M. Kay Washington,D. Brent Polk +6 more
TL;DR: The probiotic bacterium Lactobacillus rhamnosus GG and factors recovered from LGG broth culture supernatant (LGG-s) prevent cytokine-induced apoptosis in human and mouse intestinal epithelial cells by regulating signaling pathways as mentioned in this paper.
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Prostaglandin E2 Increases Growth and Motility of Colorectal Carcinoma Cells
TL;DR: The results suggest that PGE2 might enhance the invasive potential of colorectal carcinoma cells via activation of major intracellular signal transduction pathways not previously reported to be regulated by prostaglandins.
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Experimentally derived metastasis gene expression profile predicts recurrence and death in patients with colon cancer
J. Joshua Smith,Natasha G. Deane,Fei Wu,Nipun B. Merchant,Bing Zhang,Aixiang Jiang,Pengcheng Lu,J. Chad Johnson,Carl Schmidt,Christina E. Bailey,Steven A. Eschrich,Christian Kis,Shawn Levy,Shawn Levy,M. Kay Washington,Martin J. Heslin,Robert J. Coffey,Timothy J. Yeatman,Yu Shyr,R. Daniel Beauchamp +19 more
TL;DR: A gene expression profile identified from an experimental model of colon cancer metastasis predicted cancer recurrence and death, independently of conventional measures, in patients with colon cancer.
Journal ArticleDOI
Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer
Punita Dhawan,Amar B. Singh,Natasha G. Deane,Yi Ran No,Sheng Ru Shiou,Carl Schmidt,John C. Neff,M. Kay Washington,R. Daniel Beauchamp +8 more
TL;DR: Genetic manipulations of claudin-1 expression in colon cancer cell lines induced changes in cellular phenotype, with structural and functional changes in markers of epithelial-mesenchymal transition, and data is provided suggesting that the regulation of E-cadherin expression and beta-catenin/Tcf signaling is a possible mechanism underlying claudIn-1-dependent changes.