A
Agnieszka K. Grabowska
Researcher at German Cancer Research Center
Publications - 7
Citations - 766
Agnieszka K. Grabowska is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Immune system & Epitope. The author has an hindex of 5, co-authored 6 publications receiving 642 citations.
Papers
More filters
Journal ArticleDOI
A vaccine targeting mutant IDH1 induces antitumour immunity
Theresa Schumacher,Lukas Bunse,Stefan Pusch,Felix Sahm,Benedikt Wiestler,Jasmin Quandt,Oliver Menn,Matthias Osswald,Iris Oezen,Martina Ott,Melanie Keil,Jörg Balß,Katharina J. Rauschenbach,Agnieszka K. Grabowska,Isabel Vogler,Jan Diekmann,Nico Trautwein,Stefan B. Eichmüller,Jürgen G. Okun,Stefan Stevanovic,Angelika B. Riemer,Ugur Sahin,Manuel A. Friese,Philipp Beckhove,Andreas von Deimling,Wolfgang Wick,Michael Platten +26 more
TL;DR: It is demonstrated that IDH1(R132H) contains an immunogenic epitope suitable for mutation-specific vaccination and Peptides encompassing the mutated region are presented on major histocompatibility complexes (MHC) class II and induce mutation- specific CD4+ T-helper-1 (TH1) responses.
Journal ArticleDOI
The invisible enemy - how human papillomaviruses avoid recognition and clearance by the host immune system.
TL;DR: The immune evasion mechanisms employed by high-risk HPVs to escape host immune recognition and attack are reviewed.
Journal ArticleDOI
Therapeutic Vaccine Strategies against Human Papillomavirus
TL;DR: This review provides a comprehensive overview of completed and ongoing clinical trials in therapeutic HPV vaccination and highlights selected promising preclinical studies, including adjuvant science and the potential impact of novel developments in vaccinology research.
Journal ArticleDOI
Identification of promiscuous HPV16-derived T helper cell epitopes for therapeutic HPV vaccine design
TL;DR: It is concluded that the identified T helper epitopes are valuable candidates for the development of a comprehensive therapeutic HPV vaccine.
Journal ArticleDOI
ERAP1 overexpression in HPV-induced malignancies: A possible novel immune evasion mechanism.
Alina Steinbach,Jan Winter,Miriam Reuschenbach,Renata Blatnik,Alexandra Klevenz,Miriam Bertrand,Stephanie Hoppe,Magnus von Knebel Doeberitz,Agnieszka K. Grabowska,Angelika B. Riemer +9 more
TL;DR: ERAP1 overexpression may represent a novel immune evasion mechanism in HPV-induced malignancies, in cases when presentation of clinically relevant epitopes is reduced by overactivity of this peptidase.