M
Martina Ott
Researcher at University of Texas MD Anderson Cancer Center
Publications - 43
Citations - 4231
Martina Ott is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Glioma & Immune system. The author has an hindex of 18, co-authored 34 publications receiving 2993 citations. Previous affiliations of Martina Ott include University of Texas Health Science Center at Houston & German Cancer Research Center.
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Journal ArticleDOI
An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor
Christiane A. Opitz,Ulrike M. Litzenburger,Ulrike M. Litzenburger,Felix Sahm,Martina Ott,Isabel Tritschler,Saskia Trump,Theresa Schumacher,Theresa Schumacher,Leonie Jestaedt,Dieter Schrenk,Michael Weller,Manfred Jugold,Gilles J. Guillemin,Christine L. Miller,Christian Lutz,Bernhard Radlwimmer,Irina Lehmann,Andreas von Deimling,Wolfgang Wick,Michael Platten +20 more
TL;DR: Evidence is provided for a previously unidentified pathophysiological function of the AHR that is constitutively generated by human tumours via tryptophan-2,3-dioxygenase (TDO), a liver- and neuron-derived Trp-degrading enzyme not yet implicated in cancer biology.
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A vaccine targeting mutant IDH1 induces antitumour immunity
Theresa Schumacher,Lukas Bunse,Stefan Pusch,Felix Sahm,Benedikt Wiestler,Jasmin Quandt,Oliver Menn,Matthias Osswald,Iris Oezen,Martina Ott,Melanie Keil,Jörg Balß,Katharina J. Rauschenbach,Agnieszka K. Grabowska,Isabel Vogler,Jan Diekmann,Nico Trautwein,Stefan B. Eichmüller,Jürgen G. Okun,Stefan Stevanovic,Angelika B. Riemer,Ugur Sahin,Manuel A. Friese,Philipp Beckhove,Andreas von Deimling,Wolfgang Wick,Michael Platten +26 more
TL;DR: It is demonstrated that IDH1(R132H) contains an immunogenic epitope suitable for mutation-specific vaccination and Peptides encompassing the mutated region are presented on major histocompatibility complexes (MHC) class II and induce mutation- specific CD4+ T-helper-1 (TH1) responses.
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Mutational burden, immune checkpoint expression, and mismatch repair in glioma: implications for immune checkpoint immunotherapy
Tiffany R. Hodges,Martina Ott,Joanne Xiu,Zoran Gatalica,Jeff Swensen,Shouhao Zhou,Jason T. Huse,John de Groot,Shulin Li,Willem W. Overwijk,David Spetzler,Amy B. Heimberger +11 more
TL;DR: On the basis of a variety of potential biomarkers of response to immune checkpoints, only small subsets of glioma patients are likely to benefit from monotherapy immune checkpoint inhibition.
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Constitutive IDO expression in human cancer is sustained by an autocrine signaling loop involving IL-6, STAT3 and the AHR
Ulrike M. Litzenburger,Christiane A. Opitz,Felix Sahm,Felix Sahm,Katharina J. Rauschenbach,Saskia Trump,Marcus Winter,Martina Ott,Katharina Ochs,Christian Lutz,Xiangdong Liu,Natasa Anastasov,Irina Lehmann,Thomas Höfer,Andreas von Deimling,Wolfgang Wick,Michael Platten +16 more
TL;DR: Identification of the IDO-AHR-IL-6-STAT3 signaling loop maintaining IDO expression in human cancers reveals novel therapeutic targets for the inhibition of this core pathway promoting immunosuppression of human cancers.
Journal ArticleDOI
Glioblastoma stem cell-derived exosomes induce M2 macrophages and PD-L1 expression on human monocytes
Konrad Gabrusiewicz,Xu Li,Jun Wei,Yuuri Hashimoto,Anantha Marisetty,Martina Ott,Fei Wang,David H. Hawke,John Yu,Luke M. Healy,Anwar Hossain,Johnny C. Akers,Sourindra Maiti,Shinji Yamashita,Yuzaburo Shimizu,Kenneth Dunner,M. Anna Zal,Jared K. Burks,Joy Gumin,Felix Nwajei,Aras Rezavanian,Shouhao Zhou,Ganesh Rao,Raymond Sawaya,Gregory N. Fuller,Jason T. Huse,Jack P. Antel,Shulin Li,Laurence J.N. Cooper,Erik P. Sulman,Clark C. Chen,Changiz Geula,Raghu Kalluri,Tomasz Zal,Amy B. Heimberger +34 more
TL;DR: It is reported that GSC-derived exosomes (GDEs) have a predilection for monocytes, the precursor to macrophages, and data indicate that GDEs are secreted GBM-released factors that are potent modulators of the G BM-associated immunosuppressive microenvironment.