A
Ahmed M. Sh. El-Sharief
Researcher at Al-Azhar University
Publications - 24
Citations - 443
Ahmed M. Sh. El-Sharief is an academic researcher from Al-Azhar University. The author has contributed to research in topics: Reactivity (chemistry) & Nucleophile. The author has an hindex of 11, co-authored 24 publications receiving 340 citations.
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Journal ArticleDOI
Design, synthesis, antiproliferative activity, molecular docking and cell cycle analysis of some novel (morpholinosulfonyl) isatins with potential EGFR inhibitory activity
Yousry A. Ammar,Ahmed M. Sh. El-Sharief,Amany Belal,Amany Belal,Samir Y. Abbas,Yehia A. Mohamed,Ahmed B.M. Mehany,Ahmed Ragab +7 more
TL;DR: New series of 5-(morpholinosulfonyl) isatin derivatives were designed and synthesized and showed inhibitory activity against EGFR with IC50 values less than 2 μM, while the most potent EGFR inhibitors 7b and 10 showed to cause cell cycle arrest at G2/M phase and induce apoptosis.
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Design, synthesis, molecular docking and biological activity evaluation of some novel indole derivatives as potent anticancer active agents and apoptosis inducers.
Ahmed M. Sh. El-Sharief,Yousry A. Ammar,Amany Belal,Amany Belal,Marwa A.M.Sh. El-Sharief,Yehia A. Mohamed,Ahmed B.M. Mehany,Gameel A. M. El-Hag Ali,Ahmed Ragab +8 more
TL;DR: Molecular docking studies were conducted to investigate the binding mode, amino acid interactions and free binding energy of these potent derivatives, and compounds 4b, 7a and 9 showed more potent activity against EGFR than Lapatinib.
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Synthesis and radiation stability of novel biologically active sulfur compounds derived from 1,2-bis(4-amino-5-mercapto-s-triazol-3-yl)ethane
TL;DR: Some novel 1,2-bis(s-triazolo[3,4b][1,3, 4]thiadiazino-3-yl)ethane (4-7) were synthesized via reaction of 4-amino-5-mercapto-s-Triazol- 3-yl (3) with different reagents, which were promising antifungal activity and radioresistant retaining their structures unchanged up to 40 k Gy.
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Synthesis and characterization of new types of halogenated and alkylated imidazolidineiminothiones and a comparative study of their antitumor, antibacterial, and antifungal activities
TL;DR: Most tested compounds showed significant activities which could be optimized with the appropriate selection of matching aromatic substituents on N-(1) and N-(3) of the imidazolidineiminothiones.
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Some reactions with Ketene dithioacetals: Part I: Synthesis of antimicrobial pyrazolo[1,5-a]pyrimidines via the reaction of ketene dithioacetals and 5-aminopyrazoles
Medhat A. Zaharan,Ahmed M. Sh. El-Sharief,Mohamed S. A. El-Gaby,Yousry A. Ammar,U. H. El-Said +4 more
TL;DR: Pyrazolo[1,5-a]pyrimidines were synthesized via the reaction of ketene dithioacetals and 5-aminopyrazoles and the antibacterial and antifungal activities of some selected compounds are reported.