Journal ArticleDOI
Shear-Activated Nanotherapeutics for Drug Targeting to Obstructed Blood Vessels
Netanel Korin,Mathumai Kanapathipillai,Benjamin D. Matthews,Marilena Crescente,Marilena Crescente,Alexander Brill,Alexander Brill,Tadanori Mammoto,Kaustabh Ghosh,Samuel Jurek,Sidi A. Bencherif,Sidi A. Bencherif,Deen Bhatta,Ahmet U. Coskun,Charles L. Feldman,Denisa D. Wagner,Denisa D. Wagner,Donald E. Ingber,Donald E. Ingber,Donald E. Ingber +19 more
TLDR
A biomimetic strategy that uses high shear stress caused by vascular narrowing as a targeting mechanism—in the same way platelets do—to deliver drugs to obstructed blood vessels offers a potential new approach for treatment of life-threatening diseases that result from acute vascular occlusion.Abstract:
Obstruction of critical blood vessels due to thrombosis or embolism is a leading cause of death worldwide. Here, we describe a biomimetic strategy that uses high shear stress caused by vascular narrowing as a targeting mechanism--in the same way platelets do--to deliver drugs to obstructed blood vessels. Microscale aggregates of nanoparticles were fabricated to break up into nanoscale components when exposed to abnormally high fluid shear stress. When coated with tissue plasminogen activator and administered intravenously in mice, these shear-activated nanotherapeutics induce rapid clot dissolution in a mesenteric injury model, restore normal flow dynamics, and increase survival in an otherwise fatal mouse pulmonary embolism model. This biophysical strategy for drug targeting, which lowers required doses and minimizes side effects while maximizing drug efficacy, offers a potential new approach for treatment of life-threatening diseases that result from acute vascular occlusion.read more
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Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems
Mahdi Karimi,Amir Ghasemi,Parham Sahandi Zangabad,Reza Rahighi,S. Masoud Moosavi Basri,S. Masoud Moosavi Basri,Hamed Mirshekari,Mandana Amiri,Z. Shafaei Pishabad,A. Aslani,Mahnaz Bozorgomid,Deepanjan Ghosh,Ali Beyzavi,A. Vaseghi,Amir Reza Aref,L. Haghani,Sajad Bahrami,Michael R. Hamblin,Michael R. Hamblin +18 more
TL;DR: This review highlights the recent advances of smart MNPs categorized according to their activation stimulus (physical, chemical, or biological) and looks forward to future pharmaceutical applications.
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Controlling Shear Stress in 3D Bioprinting is a Key Factor to Balance Printing Resolution and Stem Cell Integrity.
Andreas Blaeser,Daniela F. Duarte Campos,Uta Puster,Walter Richtering,Molly M. Stevens,Horst Fischer +5 more
TL;DR: This work pioneers the investigation of shear stress-induced cell damage in 3D bioprinting and might help to comprehend and improve the outcome of cell-printing studies in the future.
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Managing diabetes with nanomedicine: challenges and opportunities
TL;DR: The current state of nanotechnology-based approaches for improving the care of patients with diabetes is analyzed and key issues for their translation to clinical practice are discussed.
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Organoid-on-a-chip and body-on-a-chip systems for drug screening and disease modeling.
TL;DR: Advances in tissue engineering and microfabrication technologies have enabled rapid growth in the areas of in vitro organoid development as well as organoid-on-a-chip platforms and their applications, which have the potential to dramatically impact biomedical applications in the area of drug development, drug and toxicology screening, disease modeling, and the emerging area of personalized precision medicine.
References
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