A
Ai Li Yeo
Researcher at Genome Institute of Singapore
Publications - 3
Citations - 397
Ai Li Yeo is an academic researcher from Genome Institute of Singapore. The author has contributed to research in topics: Gene & Chromatin immunoprecipitation. The author has an hindex of 3, co-authored 3 publications receiving 376 citations.
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Journal ArticleDOI
Discovery of estrogen receptor α target genes and response elements in breast tumor cells
Chin-Yo Lin,Anders Ström,Vinsensius B. Vega,Say Li Kong,Ai Li Yeo,Jane S. Thomsen,Wan Ching Chan,Balraj Doray,Dhinoth Kumar Bangarusamy,Adaikalavan Ramasamy,Liza A Vergara,Suisheng Tang,Allen Chong,Vladimir B. Bajic,Lance D. Miller,Jan-Åke Gustafsson,Edison T. Liu +16 more
TL;DR: Only a small core set of human genes appear to be sufficient to induce ER effects in breast cancer cells, and that cis-regulatory regions of these core ER target genes are poorly conserved suggests that different evolutionary mechanisms are operative at transcriptional control elements than at coding regions.
Journal ArticleDOI
Multiplatform genome-wide identification and modeling of functional human estrogen receptor binding sites.
Vinsensius B. Vega,Chin-Yo Lin,Chin-Yo Lin,Koon Siew Lai,Say Li Kong,Min Xie,Xiaodi Su,Huey Fang Teh,Jane S. Thomsen,Ai Li Yeo,Wing-Kin Sung,Guillaume Bourque,Edison T. Liu +12 more
TL;DR: Building upon a larger experimentally validated ERE set, the h-ERE algorithm is able to demarcate better the universe of ERE-like sequences that are potential ER binders, and outperformed existing predictive algorithms and produced fewer than 5% false negatives upon experimental validation.
Journal ArticleDOI
Liver X Receptors Regulate Adrenal Steroidogenesis and Hypothalamic-Pituitary-Adrenal Feedback
Maria Nilsson,Thomas M. Stulnig,Chin-Yo Lin,Ai Li Yeo,Peter Nowotny,Edison T. Liu,Knut R. Steffensen +6 more
TL;DR: LXR activation in cultured adrenal cells inhibited expression of multiple steroidogenic genes and consequently decreased adrenal steroid hormone production, and reduced expression of the glucocortioid-activating enzyme 11beta-hydroxysteroid dehydrogenase 1 in pituitary cells upon LXR activation suggests blunting of the negative feedback of glucoc Corticoids by LXRs.