D
Dhinoth Kumar Bangarusamy
Researcher at King Abdullah University of Science and Technology
Publications - 16
Citations - 1411
Dhinoth Kumar Bangarusamy is an academic researcher from King Abdullah University of Science and Technology. The author has contributed to research in topics: Gene & Population. The author has an hindex of 12, co-authored 13 publications receiving 1288 citations. Previous affiliations of Dhinoth Kumar Bangarusamy include Genome Institute of Singapore.
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Journal ArticleDOI
Human and mouse oligonucleotide-based array CGH
Paul van den IJssel,Marianne Tijssen,Suet-Feung Chin,Paul P. Eijk,Beatriz Carvalho,Erik S. Hopmans,Henne Holstege,Dhinoth Kumar Bangarusamy,Jos Jonkers,Gerrit A. Meijer,Carlos Caldas,Bauke Ylstra +11 more
TL;DR: This oligo-based platform using ‘off-the-shelf’ oligo libraries provides an easy accessible alternative to BAC arrays for CGH, which is cost-effective, available at high resolution and easily implemented for any sequenced organism without compromising the quality of the results.
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Discovery of estrogen receptor α target genes and response elements in breast tumor cells
Chin-Yo Lin,Anders Ström,Vinsensius B. Vega,Say Li Kong,Ai Li Yeo,Jane S. Thomsen,Wan Ching Chan,Balraj Doray,Dhinoth Kumar Bangarusamy,Adaikalavan Ramasamy,Liza A Vergara,Suisheng Tang,Allen Chong,Vladimir B. Bajic,Lance D. Miller,Jan-Åke Gustafsson,Edison T. Liu +16 more
TL;DR: Only a small core set of human genes appear to be sufficient to induce ER effects in breast cancer cells, and that cis-regulatory regions of these core ER target genes are poorly conserved suggests that different evolutionary mechanisms are operative at transcriptional control elements than at coding regions.
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Targeted transcriptional repression using a chimeric TALE-SRDX repressor protein
Magdy M. Mahfouz,Lixin Li,Marek J. Piatek,Xiaoyun Fang,Hicham Mansour,Dhinoth Kumar Bangarusamy,Jian-Kang Zhu +6 more
TL;DR: The data suggest that TALEs can be used to generate chimeric repressors to specifically repress the transcription of genes of interest in plants.
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Arabidopsis ECERIFERUM9 Involvement in Cuticle Formation and Maintenance of Plant Water Status
Shiyou Lü,Huayan Zhao,David L. Des Marais,Eugene P. Parsons,Xiaoxue Wen,Xiaojing Xu,Dhinoth Kumar Bangarusamy,Guangchao Wang,Owen Rowland,Thomas E. Juenger,Ray A. Bressan,Ray A. Bressan,Matthew A. Jenks +12 more
TL;DR: The CER9 protein encodes a novel determinant of plant drought tolerance-associated traits, one whose deficiency elevates cutin synthesis, redistributes wax composition, and suppresses transpiration.
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THY1 is a candidate tumour suppressor gene with decreased expression in metastatic nasopharyngeal carcinoma
Hong Lok Lung,Dhinoth Kumar Bangarusamy,Dan Xie,Dan Xie,Arthur Kwok Leung Cheung,Yue Cheng,Mande K. Kumaran,Mande K. Kumaran,Lance D. Miller,Edison T. Liu,Xin Yuan Guan,Jonathan S.T. Sham,Yan Fang,Liqiong Li,Nancy Wang,A.I. Protopopov,Eugene R. Zabarovsky,Sai Wah Tsao,Eric J. Stanbridge,Maria Li Lung +19 more
TL;DR: THY1 is a good candidate tumour suppressor gene in NPC, which is significantly associated with lymph node metastases, according to clinical study and gene expression and protein analyses.