Aileen Osborne

TL;DR: There was a modest but significant association between MAO-A polymorphism in males and disease risk and there was insufficient evidence that the other gene-environment combinations investigated modified disease risk, suggesting they contribute little to the burden of PD.

TL;DR: EGFR CNG assessed by FISH appears to identify a subgroup of patients with esophageal cancer who may benefit from gefitinib as a second-line treatment, and anti-EGFR therapies should be investigated in prospective clinical trials in different settings in EGFR FISH-positive and, in particular, EGFR-amplified esophagal cancer.

TL;DR: Evidence of statistically significant gene‐tobacco interaction for GSTM 1, NAT2, and GSTP1 is found, the negative association between tobacco smoking and PD being significantly enhanced in subjects expressing GSTM1‐1 activity, in NAT2 fast acetylators, and in those with the GSTP 1*B*C haplotype.

TL;DR: Exposure to mixed solvents is associated with impairment in colour vision, the risk increases with increasing exposure, and the risk of impairment of colour vision was not altered in this study by the presence of different GSTM1, GSTT1 or NAT2 polymorphisms.

TL;DR: In regression analyses increasing solvent exposure was associated with increasing risk of cognitive impairment, after adjustment for IQ, smoking and alcohol, and there was also an association between exposure and reduction in grip strength.