Peter Söderkvist

TL;DR: Results suggest that mutation of BRCA1 may not be critical in the development of the majority of breast and ovarian cancers that arise in the absence of a mutant germline allele.

TL;DR: A controlled study where a high frequency of nonreproducible sequence alterations was detected with the use of formalin-fixed tissues, and the presence of artifacts may have profoundly influenced previously reported mutations in formal in-fixed material, including those inserted into mutation databases.

TL;DR: A thorough summary of the genetics and clinical features of these tumors is given, both as part of the classical syndromes such as multiple endocrine neoplasia type 2 (MEN2), von Hippel-Lindau disease, neurofibromatosis type 1, and succinate dehydrogenase-related PCC-PGL and within syndrome associated with a smaller fraction of PCCs/PGLs, such as Carney triad.

TL;DR: Mitochondrial reactive oxygen species (ROS) and Nlrp3-inflammasome activation in non-myeloid-derived cells aggravate diabetic nephropathy, and targeting the inflammasomes may be a potential therapeutic approach to diabetic neophropathy.

TL;DR: Results provide support for the idea that activation of the MAP kinase pathway, especially via BRAF and KRAS mutations, is of critical importance for the development of colorectal cancer.