Aimee Zhang

TL;DR: In this paper, the authors provide evidence that TRPV4 channels in endothelial cell caveolae maintain a low pulmonary arterial pressure under normal conditions, and the activity of caveolar trpv4 channels is impaired in pulmonary arteries from mouse models of PH and PH patients.

TL;DR: Evaluated ex vivo lung perfusion of DCD lungs with low-flow targets of 20% predicted cardiac output improves lung function, reduces edema, and attenuates inflammation after transplant, and EVLP for lung rehabilitation should use reduced flow rates of 20%.

TL;DR: Pulsed ultrasound may provide cardioprotection via the cholinergic anti-inflammatory pathway and could be a promising new nonpharmacologic, noninvasive therapy to reduce infarct size during acute myocardial infarction and improve patient outcomes.

TL;DR: In this article, the authors tested the hypothesis that endothelial transient receptor potential vanilloid 4 (TRPV4) channels mediate lung ischemia-reperfusion injury (IRI), involving severe inflammation and edema, is a major cause of primary graft dysfunction following transplant.

TL;DR: In this article, it was shown that ischemically injured cardiomyocytes release cell-free DNA and HMGB1 (high mobility group box 1 protein) into circulation during reperfusion, activating pr...