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Adishesh K. Narahari
Researcher at University of Virginia
Publications - 25
Citations - 644
Adishesh K. Narahari is an academic researcher from University of Virginia. The author has contributed to research in topics: Medicine & Pannexin. The author has an hindex of 10, co-authored 22 publications receiving 383 citations. Previous affiliations of Adishesh K. Narahari include University of Virginia Health System.
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Journal ArticleDOI
BcsA and BcsB form the catalytically active core of bacterial cellulose synthase sufficient for in vitro cellulose synthesis
Okako Omadjela,Adishesh K. Narahari,Joanna Strumillo,Hugo Mélida,Olga Mazur,Vincent Bulone,Jochen Zimmer +6 more
TL;DR: Robust in vitro cellulose synthesis reconstituted from purified BcsA and BcsB proteins from Rhodobacter sphaeroides is demonstrated, thereby establishing an experimental basis for cellulose and biofilm research and revealing feedback inhibition of cellulose synthase by UDP but not by the accumulating cellulose polymer.
Journal ArticleDOI
Surgeon Scientists Are Disproportionately Affected by Declining NIH Funding Rates.
Adishesh K. Narahari,J. Hunter Mehaffey,Robert B. Hawkins,Eric J. Charles,Pranav K. Baderdinni,Anirudha S. Chandrabhatla,Joseph W. Kocan,R. Scott Jones,Gilbert R. Upchurch,Irving L. Kron,John A. Kern,Gorav Ailawadi +11 more
TL;DR: Despite declining funding over the last 10 years, surgeon scientists have demonstrated increasing productivity as measured by impactful publications and higher success rates in converting early investigator awards to R01s.
Journal ArticleDOI
Pannexin-1 channels on endothelial cells mediate vascular inflammation during lung ischemia-reperfusion injury.
Ashish Sharma,Eric J. Charles,Yunge Zhao,Adishesh K. Narahari,Pranav K. Baderdinni,Miranda E. Good,Ulrike Lorenz,Irving L. Kron,Douglas A. Bayliss,Kodi S. Ravichandran,Brant E. Isakson,Victor E. Laubach +11 more
TL;DR: This study is the first, to the authors' knowledge, to demonstrate that endothelial Panx1 plays a key role in mediating vascular permeability, inflammation, edema, leukocyte infiltration, and lung dysfunction after I/R.
Journal ArticleDOI
ATP and large signaling metabolites flux through caspase-activated Pannexin 1 channels.
Adishesh K. Narahari,Alex J. B. Kreutzberger,Pablo S. Gaete,Yu-Hsin Chiu,Susan A. Leonhardt,Christopher B. Medina,Xueyao Jin,Patrycja W. Oleniacz,Volker Kiessling,Paula Q. Barrett,Kodi S. Ravichandran,Mark Yeager,Jorge E. Contreras,Lukas K. Tamm,Douglas A. Bayliss +14 more
TL;DR: In this article, the authors demonstrate that PANX1 channels provide a molecular pathway for flux of ATP and other anionic (glutamate) and cationic signaling metabolites (spermidine).
Journal ArticleDOI
Improved outcomes and value in staged hybrid extent II thoracoabdominal aortic aneurysm repair.
Robert B. Hawkins,J. Hunter Mehaffey,Adishesh K. Narahari,Amit Jain,Ravi K. Ghanta,Irving L. Kron,John A. Kern,Gilbert R. Upchurch +7 more
TL;DR: Staged hybrid repair of extensive TAAAs is associated with fewer complications than open TAAA repair, resulting in a good value investment from a resource utilization perspective.