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Aixia Cheng
Researcher at Shandong University
Publications - 18
Citations - 605
Aixia Cheng is an academic researcher from Shandong University. The author has contributed to research in topics: Candida albicans & Medicine. The author has an hindex of 11, co-authored 11 publications receiving 515 citations.
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Plagiochin E, an antifungal active macrocyclic bis(bibenzyl), induced apoptosis in Candida albicans through a metacaspase-dependent apoptotic pathway
TL;DR: It is reported for the first time that PLE induced apoptosis in C. albicans through a metacaspase-dependent apoptotic pathway, indicating the ROS was an important mediator of PLE-induced apoptosis.
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Plagiochin E, an antifungal bis(bibenzyl), exerts its antifungal activity through mitochondrial dysfunction-induced reactive oxygen species accumulation in Candida albicans.
TL;DR: PLE exerts its antifungal activity through mitochondrial dysfunction-induced ROS accumulation in C. albicans, and this increase in the level of ROS production and PLE-induced decrease in cell viability were prevented by addition of L-cysteine, indicating that ROS was an important mediator of the ant ifungal action of PLE.
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Effect of plagiochin E, an antifungal macrocyclic bis(bibenzyl), on cell wall chitin synthesis in Candida albicans.
TL;DR: Results indicate that the antifungal activity of PLE would be attributed to its inhibitory effect on cell wall chitin synthesis in Candida albicans.
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Solamargine, a steroidal alkaloid glycoside, induces oncosis in human K562 leukemia and squamous cell carcinoma KB cells.
TL;DR: Solamargine can rapidly initiate acute injury and bursting by damaging to cellular membrane and may offer a novel therapeutic strategy in treatment of cancer.
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In Vitro Activities of Retigeric Acid B Alone and in Combination with Azole Antifungal Agents against Candida albicans
TL;DR: It is suggested that the natural product RAB may play a certain role in increasing the susceptibilities of azole-resistant C. albicans strains.