Ajay Rana

TL;DR: It is reported herein that SPRK activates the stress-activated protein kinases (SAPKs) but not ERK-1 during transient expression in COS cells; the p38 kinase is activated modestly but consistently; and Immunoprecipitated recombinant SPRK is able to phosphorylate and activate recombinant SEK- 1 in vitro to an extent comparable to that achieved by MEK kinase-1.

TL;DR: It is demonstrated that α-synuclein aggregates can induce the rupture of lysosomes following their endocytosis in neuronal cell lines, and Lysosomal rupture is known to induce mitochondrial dysfunction and inflammation, both of which are well established aspects of Parkinson's disease, thus connecting these aspects of Parker's disease to the propagation of α- synuclein pathology in cells.

TL;DR: It is demonstrated that sustained JNK activation uncouples ERK activation from MEK in a manner requiring Jun-mediated gene transcription, which points to the existence of a negative cross-talk relationship between the stress-activated JNK pathway and the mitogen-activated ERK pathway.

TL;DR: Results suggest that MLK family members are MAPK kinase kinases preferentially acting on the JNK/SAPK pathway.

TL;DR: In this review, an effort is made to study the outline of pathophysiology and various types of animal models used in the research study of IBD and other disease-related complications.