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Akanksha Thawani
Researcher at Princeton University
Publications - 13
Citations - 492
Akanksha Thawani is an academic researcher from Princeton University. The author has contributed to research in topics: Nucleation & Microtubule nucleation. The author has an hindex of 8, co-authored 13 publications receiving 319 citations. Previous affiliations of Akanksha Thawani include Indian Institute of Technology Bombay & California Institute for Quantitative Biosciences.
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XMAP215 is a microtubule nucleation factor that functions synergistically with the γ-tubulin ring complex.
TL;DR: It is reported that the well-characterized MT polymerase XMAP215 (chTOG/Msps/Stu2p/Alp14/Dis1 homologue) is essential for MT nucleation in Xenopus egg extracts and in vitro, challenging the view that γ-TuRC alone is the universal nucleator of the cell.
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Structural analysis of the role of TPX2 in branching microtubule nucleation
TL;DR: The domain organization of Xenopus laevis TPX2 is established and the minimal TPX1 version that stimulates branching MT nucleation is defined, which is unrelated to TPX 2’s ability to nucleate MTs in vitro.
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Mechanism of how augmin directly targets the γ-tubulin ring complex to microtubules
TL;DR: The finding that augmin can directly bridge MTs with &ggr;-TuRC via these two tetramers adds to the mechanistic understanding of how MTs can be nucleated from preexisting MTs.
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Spatiotemporal organization of branched microtubule networks.
TL;DR: Regulating the localization and kinetics of nucleation effectors governs the architecture of branched MT networks, and it is shown that first TPX2 is deposited on pre-existing MTs, followed by binding of augmin/γ-TuRC to result in the nucleation of brANChed MTs.
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Biochemical reconstitution of branching microtubule nucleation.
TL;DR: This work biochemically reconstitute branching microtubule nucleation, which is critical for chromosome segregation, and provides a blueprint for other microtubul nucleation pathways and helps explain how microtubules are generated in the spindle.