Akio A. Awa

TL;DR: An analysis of the utility of fluorescence in situ hybridization with whole-chromosome probes for measurement of the genomic frequency of translocations found in the peripheral blood of individuals exposed to ionizing radiation shows that translocation frequency dose response curves estimated using FISH are similar for Hiroshima A-bomb survivors and for first division lymphocytes irradiated in vitro.

TL;DR: The working group believes that with prompt peripheral blood sampling, external doses to individuals of the order of about 10 rad (or less if the exposure was to high-LET radiation) can accurately be detected and measured and does not believe that cytogenetic measurements can detect internal doses from fallout radionuclides in individuals unless these are very large.

TL;DR: The estimation of the magnitude of a dose ionizing radiation to which an individual has been exposed from chromosomal aberration frequencies determined in peripheral blood lymphocyte cultures is a well-established methodology, having first been employed over 25 y ago as discussed by the authors.

TL;DR: The results indicate that HPRT mutation in vivo in human T-cells could be detected in these survivors 40 years after the presumed mutational event.