A
Akira Miyazato
Researcher at University of Tokyo
Publications - 18
Citations - 641
Akira Miyazato is an academic researcher from University of Tokyo. The author has contributed to research in topics: Proto-oncogene tyrosine-protein kinase Src & TEC. The author has an hindex of 11, co-authored 18 publications receiving 621 citations.
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Identification of myelodysplastic syndrome-specific genes by DNA microarray analysis with purified hematopoietic stem cell fraction.
Akira Miyazato,Shuichi Ueno,Ken Ohmine,Masuzu Ueda,Koji Yoshida,Yoshihiro Yamashita,Takashi Kaneko,Masaki Mori,Keita Kirito,Masaki Toshima,Yuichi Nakamura,Kenji Saito,Yasuhiko Kano,Shinpei Furusawa,Keiya Ozawa,Hiroyuki Mano +15 more
TL;DR: Examination of the Blast Bank samples from 22 patients with MDS, 31 with AML, and 8 with chronic myeloid leukemia confirmed the highly selective expression of the Dlk gene, which could be the first candidate molecule to differentiate MDS from AML.
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SOCS-1/JAB/SSI-1 Can Bind to and Suppress Tec Protein-tyrosine Kinase *
Ken-ichi Ohya,Sachiko Kajigaya,Yoshihiro Yamashita,Akira Miyazato,Kiyohiko Hatake,Yasusada Miura,Uichi Ikeda,Kazuyuki Shimada,Keiya Ozawa,Hiroyuki Mano +9 more
TL;DR: It is proposed that SOCS- 1/JAB/SSI-1/TIP3 is a novel type of negative regulator to a subset of protein-tyrosine kinases to obscure how Tec relays the signals from cell surface receptors to the nucleus.
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Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase
Ken-ichi Ohya,Sachiko Kajigaya,Akira Kitanaka,Koji Yoshida,Akira Miyazato,Yoshihiro Yamashita,Takeo Yamanaka,Uichi Ikeda,Kazuyuki Shimada,Keiya Ozawa,Hiroyuki Mano +10 more
TL;DR: BRDG1 appears to function as a docking protein acting downstream of Tec in BCR signaling, and was shown to participate in a positive feedback loop by increasing the activity of Tec.
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Tec and Jak2 Kinases Cooperate to Mediate Cytokine-Driven Activation of c-fos Transcription
Yoshihiro Yamashita,Sumiko Watanabe,Akira Miyazato,Ken-ichi Ohya,Uichi Ikeda,Kazuyuki Shimada,Norio Komatsu,Kiyohiko Hatake,Yasusada Miura,Keiya Ozawa,Hiroyuki Mano +10 more
TL;DR: It is presented here that Tec PTK is tyrosine-phosphorylated and activated by granulocyte-macrophage colony-stimulating factor (GM-CSF) stimulation in a human GM- CSF–dependent cell line and that Tec and Jak2 can “cross-talk” in a complexed way to mediate cytokine-driven c- fos activation.
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Severe hepatitis and complete molecular response caused by imatinib mesylate: possible association of its serum concentration with clinical outcomes.
Satoru Kikuchi,Kazuo Muroi,Satoko Takahashi,Chizuru Kawano-Yamamoto,Masaaki Takatoku,Akira Miyazato,Tadashi Nagai,Masaki Mori,Norio Komatsu,Keiya Ozawa +9 more
TL;DR: Results suggest that both hepatitis and molecular response were associated with the serum STI571 concentration, which is consistent with drug-induced hepatitis.