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Akira Sato
Researcher at Tokyo University of Science
Publications - 102
Citations - 1305
Akira Sato is an academic researcher from Tokyo University of Science. The author has contributed to research in topics: Apoptosis & Programmed cell death. The author has an hindex of 18, co-authored 102 publications receiving 1064 citations. Previous affiliations of Akira Sato include National Cancer Research Institute & Aichi Gakuin University.
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An unnatural hydrophobic base pair system: site-specific incorporation of nucleotide analogs into DNA and RNA
Ichiro Hirao,Michiko Kimoto,Tsuneo Mitsui,Tsuyoshi Fujiwara,Rie Kawai,Akira Sato,Yoko Harada,Shigeyuki Yokoyama +7 more
TL;DR: An unnatural base Pair system in which DNA containing an unnatural base pair can be amplified and function as a template for the site-specific incorporation of base analog substrates into RNA via transcription is presented.
Journal ArticleDOI
Site-specific functionalization of RNA molecules by an unnatural base pair transcription system via click chemistry
TL;DR: The combination of unnatural base pair transcription and post-transcriptional modification by click chemistry enables simple RNA labeling with a wide variety of functional groups at desired positions, in a one-pot reaction.
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Effects of 3-styrylchromones on metabolic profiles and cell death in oral squamous cell carcinoma cells
Hiroshi Sakagami,Chiyako Shimada,Yumiko Kanda,Osamu Amano,Masahiro Sugimoto,Sana Ota,Tomoyoshi Soga,Masaru Tomita,Akira Sato,Sei-ichi Tanuma,Koichi Takao,Yoshiaki Sugita +11 more
TL;DR: The most cytotoxic compound 11, induced the mitochondrial vacuolization, autophagy suppression followed by apoptosis induction, and changes in the metabolites involved in amino acid and glycerophospholipid metabolisms, suggesting chemical modification of lead compound 11 may be a potential choice for designing new type of anticancer drugs.
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Andirolides H–P from the flower of andiroba (Carapa guianensis, Meliaceae)
Yuji Tanaka,Asami Sakamoto,Takanobu Inoue,Takeshi Yamada,Takashi Kikuchi,Tetsuya Kajimoto,Osamu Muraoka,Akira Sato,Yusuke Wataya,Hye Sook Kim,Reiko Tanaka +10 more
TL;DR: In this paper, three new gedunins, an andirobin, three mexicanolides, and two phragmalin-type limonoids named andirolides were isolated from an oil of the flower of Carapa guianensis A ublet (Meliaceae) and their structures including the absolute configurations were determined by means of the NMR and CD spectra as well as FABMS.
Journal ArticleDOI
Site-specific incorporation of functional components into RNA by an unnatural base pair transcription system.
TL;DR: It is found that the efficient incorporation into a position close to the 3′-terminus of a transcript depended on the natural base contexts neighboring the unnatural base, and that pyrimidine-Ds-pyrimidine sequences in templates were generally favorable, relative to purine-Ds -purine sequences.