M
Masahiro Sugimoto
Researcher at Tokyo Medical University
Publications - 181
Citations - 6746
Masahiro Sugimoto is an academic researcher from Tokyo Medical University. The author has contributed to research in topics: Medicine & Metabolomics. The author has an hindex of 35, co-authored 157 publications receiving 5356 citations. Previous affiliations of Masahiro Sugimoto include Yamagata University & University of Rajshahi.
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Journal ArticleDOI
Quantitative Metabolome Profiling of Colon and Stomach Cancer Microenvironment by Capillary Electrophoresis Time-of-Flight Mass Spectrometry
Akiyoshi Hirayama,Kenjiro Kami,Masahiro Sugimoto,Maki Sugawara,Naoko Toki,Hiroko Onozuka,Taira Kinoshita,Norio Saito,Atsushi Ochiai,Masaru Tomita,Hiroyasu Esumi,Tomoyoshi Soga +11 more
TL;DR: Capillary electrophoresis coupled to mass spectrometry-based metabolomics, which is capable of quantifying the levels of energy metabolites in tissues, could be a powerful tool for the development of novel anticancer agents that target cancer-specific metabolism.
Journal ArticleDOI
Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles
Masahiro Sugimoto,David T.W. Wong,David T.W. Wong,Akiyoshi Hirayama,Tomoyoshi Soga,Masaru Tomita +5 more
TL;DR: A comprehensive metabolite analysis of saliva samples obtained from 215 individuals using capillary electrophoresis time-of-flight mass spectrometry identified 57 principal metabolites that can be used to accurately predict the probability of being affected by each individual disease.
Journal ArticleDOI
Bioinformatics Tools for Mass Spectroscopy-Based Metabolomic Data Processing and Analysis.
TL;DR: A state-of-the-art overview of the data processing tools available is provided, with their advantages and disadvantages, and comparisons are made to guide the reader.
Journal ArticleDOI
Measurement of internal body time by blood metabolomics
Yoichi Minami,Takeya Kasukawa,Yuji Kakazu,Masayuki Iigo,Masahiro Sugimoto,Masahiro Sugimoto,Satsuki Ikeda,Akira Yasui,Gijsbertus T. J. van der Horst,Tomoyoshi Soga,Hiroki R. Ueda +10 more
TL;DR: The results suggest the potential for metabolomics-based detection of BT (“metabolite-timetable method”), which will lead to the realization of chronotherapy and personalized medicine.
Journal ArticleDOI
Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC
Kiyotoshi Satoh,Shinichi Yachida,Masahiro Sugimoto,Minoru Oshima,Toshitaka Nakagawa,Shintaro Akamoto,Sho Tabata,Kaori Saitoh,Keiko Kato,Saya Sato,Kaori Igarashi,Yumi Aizawa,Rie Kajino-Sakamoto,Yasushi Kojima,Teruaki Fujishita,Ayame Enomoto,Akiyoshi Hirayama,Takamasa Ishikawa,Makoto Mark Taketo,Yoshio Kushida,Reiji Haba,Keiichi Okano,Masaru Tomita,Yasuyuki Suzuki,Shinji Fukuda,Masahiro Aoki,Tomoyoshi Soga +26 more
TL;DR: It is shown that metabolic reprogramming of colorectal cancer is caused chiefly by aberrant MYC expression, and inhibition of MYC target pyrimidine synthesis genes such as CAD, UMPS, and CTPS blocked cell growth, and thus are potential targets for coloreCTal cancer therapy.