A
Akito Eguchi
Researcher at Temple University
Publications - 9
Citations - 445
Akito Eguchi is an academic researcher from Temple University. The author has contributed to research in topics: Heart failure & Angiotensin II. The author has an hindex of 5, co-authored 8 publications receiving 314 citations.
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Journal ArticleDOI
New Insights in Cardiac β-Adrenergic Signaling During Heart Failure and Aging.
TL;DR: Therapies which restore β-ARs responsiveness can ameliorate cardiac performance and outcomes during HF, particularly in older patients, as well as the potential clinical application of targeting β-adrenergic signaling in these disease processes.
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SPG7 Is an Essential and Conserved Component of the Mitochondrial Permeability Transition Pore.
Santhanam Shanmughapriya,Sudarsan Rajan,Nicholas E. Hoffman,Andrew Higgins,Dhanendra Tomar,Neeharika Nemani,Kevin J. Hines,Dylan J. Smith,Akito Eguchi,Sandhya Vallem,Farah Shaikh,Maggie Cheung,Nicole J. Leonard,Ryan S. Stolakis,Matthew P. Wolfers,Jessica Ibetti,J. Kurt Chuprun,Neelakshi R. Jog,Steven R. Houser,Walter J. Koch,John W. Elrod,Muniswamy Madesh +21 more
TL;DR: A necessary and conserved role for spastic paraplegia 7 (SPG7) is identified in Ca(2+)- and ROS-induced PTP opening using RNAi-based screening and biochemical analyses revealed that the PTP is a heterooligomeric complex composed of VDAC, SPG7, and CypD.
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Myocardial pathology induced by aldosterone is dependent on non-canonical activities of G protein-coupled receptor kinases.
Alessandro Cannavo,Daniela Liccardo,Akito Eguchi,Katherine J. Elliott,Christopher J. Traynham,Jessica Ibetti,Satoru Eguchi,Dario Leosco,Nicola Ferrara,Giuseppe Rengo,Walter J. Koch +10 more
TL;DR: GRKs are uncovered as targets for ameliorating pathological cardiac effects associated with high-aldosterone levels and are shown to involve cross-talk with the angiotensin II type-1 receptor (AT1R) in heart failure.
Journal ArticleDOI
GRK5 is a regulator of fibroblast activation and cardiac fibrosis
Akito Eguchi,Ryan C. Coleman,Kenneth S. Gresham,Erhe Gao,Jessica Ibetti,J. Kurt Chuprun,Walter J. Koch +6 more
TL;DR: In this paper, a genetic deletion of G protein-coupled receptor kinase 5 (GRK5) inhibited angiotensin II (AngII)-mediated fibroblast activation.
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Perturbation of the interactions of calmodulin with GRK5 using a natural product chemical probe
Tyler S. Beyett,Amy E. Fraley,Emily Labudde,Dhabaleswar Patra,Ryan C. Coleman,Akito Eguchi,Alisa Glukhova,Qiuyan Chen,Robert M. Williams,Walter J. Koch,David H. Sherman,John J.G. Tesmer +11 more
TL;DR: In cells, malbrancheamide attenuated GRK5 nuclear translocation and effectively blocked the hypertrophic response, demonstrating the utility of this natural product and its derivatives in probing Ca2+·CaM-dependent hypertrophy.