Akram Thabet Nasher

TL;DR: Functional prediction showed that genes involved in bacterial mobility, flagellar assembly, bacterial chemotaxis and LPS synthesis were enriched in the tumors while those responsible for DNA repair and combination, purine metabolism, phenylalanine, tyrosine and tryptophan biosynthesis, ribosome biogenesis and glycolysis/gluconeogenesis were significantly associated with the controls.

TL;DR: A robust algorithm for species-level classification of NGS reads from oral samples is developed and pilot test it for profiling bacteria within OSCC tissues, ensuring reliable classification by giving priority to the human, oral reference set.

TL;DR: There was a trend for higher number of mutations, amplifications and driver events in samples with history of shammah exposure particularly those that tested EBV positive, suggesting an interaction between tobacco exposure and EBV.

TL;DR: Shammh use is a major risk factor for oral cancer in Yemen and the association of shammah use alone with OSCC exceeded that of shamsah use in combination with qat chewing, smoking, or both.

TL;DR: The EBV latent membrane protein 1 (LMP1), an active transmembrane receptor, appears to mediate malignant transformation by activating the nuclear-factor-kappa B (NF-ᴋB), c-Jun N-terminal kinase (JNK) and phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathways as mentioned in this paper.