Aladin Haimovici

TL;DR: T cells are crucial effectors of glioma rejection induced by local IL-12 application and CTLA-4 blockade and are recruited by the immune system through T-cell reprograming.

TL;DR: In this article , the authors tested whether spontaneously appearing micronuclei in cancer cells are linked to sub-lethal apoptotic signals and found that low-level activity in the mitochondrial apoptosis apparatus operates through CAD-dependent gene induction and STING-activation and has substantial impact on metastasis in cancer patients.

TL;DR: In this article , the authors show that the host cell's mitochondrial apoptosis system contributes to cytokine secretion and DNA-damage in the absence of cell death, and that DNA damage through sub-lethal mitochondrial signals is likely to contribute to mutagenesis and cancer development.

TL;DR: In this article , the authors suggest that small-scale mitochondrial outer membrane permeabilization is an accident, a leakiness of the apoptosis apparatus, perhaps during restructuring of the mitochondrial network.