G
Gabriel Ichim
Researcher at University of Lyon
Publications - 46
Citations - 2223
Gabriel Ichim is an academic researcher from University of Lyon. The author has contributed to research in topics: Apoptosis & Programmed cell death. The author has an hindex of 17, co-authored 36 publications receiving 1690 citations. Previous affiliations of Gabriel Ichim include International Agency for Research on Cancer & French Institute of Health and Medical Research.
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Journal ArticleDOI
A fate worse than death: apoptosis as an oncogenic process
Gabriel Ichim,Stephen W.G. Tait +1 more
TL;DR: It is argued that fully understanding this dark side will be required to optimally engage apoptosis, thereby maximizing tumour cell kill while minimizing unwanted pro-tumorigenic effects.
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Die another way – non-apoptotic mechanisms of cell death
TL;DR: Several regulated non-apoptotic forms of cell death including necroptosis, autophagic cell death, pyroptosis and caspase-independent cell death are discussed, outlining what the authors know about their mechanism, potential roles in vivo and define outstanding questions.
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Limited Mitochondrial Permeabilization Causes DNA Damage and Genomic Instability in the Absence of Cell Death
Gabriel Ichim,Jonathan Lopez,Shafiq U. Ahmed,Nathiya Muthalagu,Evangelos Giampazolias,M. Eugenia Delgado,Martina Haller,Joel S. Riley,Susan M. Mason,Dimitris Athineos,Melissa J. Parsons,Melissa J. Parsons,Bert van de Kooij,Lisa Bouchier-Hayes,Lisa Bouchier-Hayes,Anthony J. Chalmers,Rogier W. Rooswinkel,Andrew Oberst,Karen Blyth,Markus Rehm,Daniel J. Murphy,Stephen W.G. Tait +21 more
TL;DR: It is demonstrated that, in contrast to its well-established tumor suppressor function, apoptosis also has oncogenic potential that is regulated by the extent of MOMP, and these findings have important implications for oncogenesis following either physiological or therapeutic engagement of apoptosis.
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Widespread Mitochondrial Depletion via Mitophagy Does Not Compromise Necroptosis
Stephen W.G. Tait,Andrew Oberst,Giovanni Quarato,Sandra Milasta,Martina Haller,Ruoning Wang,Maria Karvela,Gabriel Ichim,Nader Yatim,Matthew L. Albert,Grahame J. Kidd,Randall Wakefield,Sharon Frase,Stefan Krautwald,Andreas Linkermann,Douglas R. Green +15 more
TL;DR: It is indicated that mitochondrial ROS production accompanies, but does not cause, RIPK3-dependent necroptotic cell death.
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Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency
Evangelos Giampazolias,Barbara Zunino,Sandeep Dhayade,Florian J. Bock,Catherine Cloix,Kai Cao,Alba Roca,Jonathan Lopez,Jonathan Lopez,Gabriel Ichim,Gabriel Ichim,Emma Proïcs,Camila Rubio-Patiño,Loic Fort,Nader Yatim,Emma F. Woodham,Susana Orozco,Lucia Taraborrelli,Nieves Peltzer,Daniele Lecis,Laura M. Machesky,Henning Walczak,Matthew L. Albert,Matthew L. Albert,Simon Milling,Andrew Oberst,Jean-Ehrland Ricci,Kevin M. Ryan,Karen Blyth,Stephen W.G. Tait +29 more
TL;DR: The data demonstrate that by activating NF-κB, MOMP can exert additional signalling functions besides triggering cell death, and support a rationale for engaging caspase-independent cell death in cell-killing anti-cancer therapies.