A
Arnim Weber
Researcher at University of Freiburg
Publications - 31
Citations - 1483
Arnim Weber is an academic researcher from University of Freiburg. The author has contributed to research in topics: Apoptosis & Mitochondrion. The author has an hindex of 17, co-authored 25 publications receiving 1227 citations. Previous affiliations of Arnim Weber include University Medical Center Freiburg & Technische Universität München.
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Journal ArticleDOI
Time-Dependent Proteome Alterations under Osmotic Stress during Aerobic and Anaerobic Growth in Escherichia coli
TL;DR: Comparative analysis of the proteome of E. coli grown under aerobic or anaerobic conditions under osmotic stress (NaCl) revealed an overlap of the up-regulated proteins of more than 50%.
Journal ArticleDOI
Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells.
Nimitha R. Mathew,Nimitha R. Mathew,Francis Baumgartner,Lukas Braun,David O’Sullivan,Simone Thomas,Miguel Waterhouse,Tony Andreas Müller,Kathrin Hanke,Kathrin Hanke,Sanaz Taromi,Petya Apostolova,Anna Lena Illert,Wolfgang Melchinger,Sandra Duquesne,Annette Schmitt-Graeff,Lena Osswald,Kai-Li Yan,Arnim Weber,Sonia Tugues,Sabine Spath,Dietmar Pfeifer,Marie Follo,Rainer Claus,Michael Lübbert,Christoph Rummelt,Hartmut Bertz,Ralph Wäsch,Johanna Haag,Andrea Schmidts,Michael Schultheiss,Dominik Bettinger,Robert Thimme,Evelyn Ullrich,Yakup Tanriver,Giang Lam Vuong,Renate Arnold,Philipp Hemmati,Dominik Wolf,Markus Ditschkowski,Cordula A. Jilg,Konrad Wilhelm,C. Leiber,Sabine Gerull,Jörg Halter,Claudia Lengerke,Thomas Pabst,Thomas Schroeder,Guido Kobbe,Wolf Rösler,Soroush Doostkam,Stephan Meckel,Kathleen Stabla,Kathleen Stabla,S K Metzelder,S K Metzelder,Sebastian Halbach,Tilman Brummer,Zehan Hu,Zehan Hu,Joern Dengjel,Joern Dengjel,Björn Hackanson,Christoph Schmid,Udo Holtick,Christof Scheid,Alexandros Spyridonidis,Friedrich Stölzel,Rainer Ordemann,Lutz P. Müller,Flore Sicre-de-Fontbrune,Gabriele Ihorst,Jürgen Kuball,Jan E. Ehlert,Daniel Feger,Eva-Maria Wagner,Jean-Yves Cahn,Jacqueline Schnell,Florian Kuchenbauer,Donald Bunjes,Ronjon Chakraverty,Simon Richardson,Saar Gill,Nicolaus Kröger,Francis Ayuk,Luca Vago,Fabio Ciceri,Antonia M.S. Müller,Takeshi Kondo,Takanori Teshima,Susan Klaeger,Susan Klaeger,Bernhard Kuster,Dennis Dong Hwan Kim,Daniel J. Weisdorf,Walter J.F.M. van der Velden,Daniela Dörfel,Wolfgang Bethge,Inken Hilgendorf,Andreas Hochhaus,Geoffroy Andrieux,Melanie Börries,Hauke Busch,John M. Magenau,Pavan Reddy,Myriam Labopin,Joseph H. Antin,Andrea S. Henden,Andrea S. Henden,Geoffrey R. Hill,Geoffrey R. Hill,Glen A Kennedy,Merav Bar,Anita Sarma,Donal P. McLornan,Ghulam J. Mufti,Betul Oran,Katayoun Rezvani,Omid Shah,Robert S. Negrin,Arnon Nagler,Marco Prinz,Marco Prinz,Andreas Burchert,Andreas Neubauer,Andreas Neubauer,Dietrich W. Beelen,Andreas Mackensen,Nikolas von Bubnoff,Wolfgang Herr,Burkhard Becher,Gérard Socié,Michael A. Caligiuri,Eliana Ruggiero,Chiara Bonini,Georg Häcker,Justus Duyster,Jürgen Finke,Erika L. Pearce,Bruce R. Blazar,Robert Zeiser,Robert Zeiser +141 more
TL;DR: Findings indicate that the synergism of T cells and sorafenib is mediated via reduced ATF4 expression, causing activation of the IRF7–IL-15 axis in leukemia cells and thereby leading to metabolic reprogramming of leukemia-reactive T cells in humans.
Journal ArticleDOI
Profiling early osmostress-dependent gene expression in Escherichia coli using DNA macroarrays.
Arnim Weber,Kirsten Jung +1 more
TL;DR: DNA macroarray technology was used to monitor early transcriptional alterations of Escherichia coli in response to an osmotic upshift imposed by the addition of 0.4 M NaCl; 45 genes showed increased expression while the expression of the remaining 107 genes was reduced.
Journal ArticleDOI
Proapoptotic signalling through Toll-like receptor-3 involves TRIF-dependent activation of caspase-8 and is under the control of inhibitor of apoptosis proteins in melanoma cells.
TL;DR: The results indicate that the proapoptotic activity of TLR3/TRIF/caspase-8 in melanoma cells is under the control of IAPs, and the use of novel Smac mimetics might be a feasible approach to target melanoma.
Journal ArticleDOI
BimS-induced apoptosis requires mitochondrial localization but not interaction with anti-apoptotic Bcl-2 proteins
Arnim Weber,Stefan A. Paschen,Klaus Heger,Florian Wilfling,Tobias Frankenberg,Heike Bauerschmitt,Barbara M. Seiffert,Susanne Kirschnek,Hermann Wagner,Georg Häcker +9 more
TL;DR: Analysis of BimS showed that mitochondrial targeting, but not binding to Bcl-2 or Mcl-1, was required for apoptosis induction, and cell death induction by a BH3-only protein can occur through a process that is independent of anti-apoptotic BCl-2 proteins but requires mitochondrial targeting.