A
Alain Laederach
Researcher at University of North Carolina at Chapel Hill
Publications - 95
Citations - 4724
Alain Laederach is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: RNA & Gene. The author has an hindex of 34, co-authored 88 publications receiving 4078 citations. Previous affiliations of Alain Laederach include New York State Department of Health & University of Neuchâtel.
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Journal ArticleDOI
Arg343 in human surfactant protein D governs discrimination between glucose and N-acetylglucosamine ligands.
Martin J. Allen,Alain Laederach,Peter J. Reilly,Robert J. Mason,Robert J. Mason,Dennis R. Voelker,Dennis R. Voelker +6 more
TL;DR: Data demonstrate that Arg343 is critical for hSP-D recognition specificity and plays a key role in defining ligand specificity differences between MBP and SP-D and suggest that the number of binding orientations contributes to monosaccharide binding affinity.
Journal ArticleDOI
Using SHAPE-MaP To Model RNA Secondary Structure and Identify 3'UTR Variation in Chikungunya Virus.
Emily A Madden,Kenneth S. Plante,Clayton R. Morrison,Katrina M. Kutchko,Wes Sanders,Kristin M. Long,Sharon Taft-Benz,Marta C Cruz Cisneros,Ashlyn Morgan White,Sanjay Sarkar,Grace Reynolds,Heather A. Vincent,Alain Laederach,Nathanial J Moorman,Mark T. Heise +14 more
TL;DR: This analysis demonstrates that the CHIKV genome contains a number of unique, specific RNA secondary structures and provides a strategy for testing these secondary structures for functional importance in Chikungunya virus replication and pathogenesis.
Posted ContentDOI
To knot and not: Multiple conformations of the SARS-CoV-2 frameshifting RNA element
Tamar Schlick,Tamar Schlick,Tamar Schlick,Qiyao Zhu,Abhishek Dey,Swati Jain,Shuting Yan,Alain Laederach +7 more
TL;DR: The authors showed that the 3-stem H-type pseudoknot (3_6 dual graph) is replaced by a different, HL-type 3-stem pseudoknon (3-3) as more residues, in particular the slippery sites 7 residues, are considered.
Journal ArticleDOI
Informatics challenges in structured RNA
TL;DR: This work reviews several important classes of structured RNAs that present the computational community with a series of biologically novel informatics challenges and reviews available informatics tools that have been recently developed in the field.
Posted ContentDOI
To knot or not to knot: Multiple conformations of the SARS-CoV-2 frameshifting RNA element.
TL;DR: This article showed that the 3-stem H-type pseudoknot (3_6 dual graph), long assumed to be the dominant structure has a viable alternative, an HL-type 3-way junction RNA (3-5) emerges as a minor conformation, while the different Stem 2 may be involved in a conformational switch and possibly associations with the ribosome during translation.