Tamar Schlick

TL;DR: In this paper, the effects of degrading cohesin were explored, showing that loop domains can be eliminated and re-formed in under an hour, consistent with a model where loop extrusion is rapid.

TL;DR: This new text is to introduce students to molecular modeling and simulation and to the wide range of biomolecular problems being attacked by computational techniques and should appeal to beginning graduate students in medical schools, and in many scientific departments such as biology, chemistry, physics, mathematics and computer science.

TL;DR: All loop domains are eliminated, but neither compartment domains nor histone marks are affected, and many megabase-sized loops recovered in under an hour, consistent with a model where loop extrusion is rapid.

TL;DR: Diffpack as discussed by the authors is a modern software development environment based on C++ and object-oriented programming for solving partial differential equations, including heat transfer, elasticity, and viscous fluid flow.

TL;DR: The results show that the 2-start zigzag topology and the type of linker DNA bending that defines solenoid models may be simultaneously present in a structurally heteromorphic chromatin fiber with uniform 30 nm diameter and suggest that dynamic linkerDNA bending by linker histones and divalent cations in vivo may mediate the transition between tight nucleosome packing within discrete 30-nm fibers and self-associated higher-order chromosomal forms.