A
Alain Laederach
Researcher at University of North Carolina at Chapel Hill
Publications - 95
Citations - 4724
Alain Laederach is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: RNA & Gene. The author has an hindex of 34, co-authored 88 publications receiving 4078 citations. Previous affiliations of Alain Laederach include New York State Department of Health & University of Neuchâtel.
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Evaluation of the information content of RNA structure mapping data for secondary structure prediction
TL;DR: This work generates "decoy" RNA structures using the sFold Boltzmann sampling procedure, and is able to directly visualize the structural information content of structure mapping data and reconcile multiple data sets, and proposes a novel approach for visualizing the interaction of chemical and enzymatic mapping data with RNA structure.
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Multiple conformations are a conserved and regulatory feature of the RB1 5′ UTR
Katrina M. Kutchko,Wes Sanders,Ben Ziehr,Gabriela Phillips,Amanda Solem,Matthew Halvorsen,Kevin M. Weeks,Nathaniel J. Moorman,Alain Laederach +8 more
TL;DR: The data suggest that selective pressure will favor multiple conformations in eukaryotic UTRs to regulate expression, which is likely causative of the cancer.
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Polysaccharide Recognition by Surfactant Protein D: Novel Interactions of a C-Type Lectin with Nonterminal Glucosyl Residues†
TL;DR: Using various soluble glucosyl homopolysaccharides as inhibitors of SP-D carbohydrate binding, this study confirmed the interactions predicted by the modeling studies and found significant hydrogen bonding between the protein and the vicinal, equatorial OH groups at the 3 and 4 positions on the sugar ring.
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Distinct contribution of electrostatics, initial conformational ensemble, and macromolecular stability in RNA folding.
TL;DR: This study showcases a robust approach for the development of kinetic models from collections of local structural probes and defines the folding landscape of the L-21 Tetrahymena thermophila group I intron structurally and kinetically from its earliest steps with unprecedented accuracy.
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Energy barriers, pathways, and dynamics during folding of large, multidomain RNAs.
TL;DR: This review explores recent studies that characterize the dominant pathways by which RNA folds, structural and dynamic features of intermediates that populate the folding landscape, and the energy barriers that separate the distinct steps of the folding process.