A
Alain Laederach
Researcher at University of North Carolina at Chapel Hill
Publications - 95
Citations - 4724
Alain Laederach is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: RNA & Gene. The author has an hindex of 34, co-authored 88 publications receiving 4078 citations. Previous affiliations of Alain Laederach include New York State Department of Health & University of Neuchâtel.
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DissertationDOI
Protein-carbohydrate and protein-protein interactions: using models to better understand and predict specific molecular recognition
TL;DR: The aim of this monograph is to demonstrate the efforts towards in-situ applicability of EMMARM, as to provide real-time information about concrete mechanical properties such as E-modulus and compressive strength.
Posted ContentDOI
Cigarette Smoking-Associated Isoform Switching and 3-prime UTR Lengthening Via Alternative Polyadenylation
Zhonghui Xu,Zhonghui Xu,John Platig,John Platig,Sool Lee,Sool Lee,Adel Boueiz,Rob Chase,Rob Chase,Dhawal Jain,Andrew Gregory,Andrew Gregory,Rahul Suryadevara,Seth Berman,Russell P. Bowler,Craig P. Hersh,Craig P. Hersh,Alain Laederach,Peter J. Castaldi,Peter J. Castaldi +19 more
TL;DR: In this article, the association of current smoking with differential expression of genes and isoforms and differential usage of isoform and exons was assessed, where current smokers were found to have higher expression and use of isoforms with markedly longer 3′ UTRs.
Journal ArticleDOI
Structural analysis of MALAT1 long noncoding RNA in cells and in evolution
TL;DR: In this paper , the in-cell and cell-free structures of the full-length human and green monkey (Chlorocebus sabaeus) MALAT1 transcripts in multiple tissue-derived cell lines using SHAPE chemical probing were investigated.
Posted ContentDOI
Structural conservation of MALAT1 long non-coding RNA in cells and in evolution
TL;DR: The uniformity of the structural conservation across the entire transcript suggests that, despite seeing co-variation signals only in the three-helix junction of the lncRNA, the rest of the transcript’s structure is remarkably conserved at least in primates and across multiple cell types and conditions.
Posted ContentDOI
Quantitative prediction of variant effects on alternative splicing using endogenous pre-messenger RNA structure probing
Jayashree Kumar,Lela Lackey,Lela Lackey,Justin M. Waldern,Abhishek Dey,David H. Mathews,Alain Laederach +6 more
TL;DR: In this paper, the authors used a novel Mutational Profiling (-MaP) methodology to obtain highly reproducible endogenous precursor and mature mRNA structural probing data in vivo, and used these data to estimate Boltzmann suboptimal ensembles, and predict the structural consequences of mutations on precursor mRNA structure.