A
Alain Pluen
Researcher at University of Manchester
Publications - 48
Citations - 4053
Alain Pluen is an academic researcher from University of Manchester. The author has contributed to research in topics: Ionic strength & Cell-penetrating peptide. The author has an hindex of 17, co-authored 46 publications receiving 3733 citations. Previous affiliations of Alain Pluen include RMIT University & Manchester Academic Health Science Centre.
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Journal ArticleDOI
Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation.
Edward B. Brown,Trevor D. McKee,Emmanuelle diTomaso,Alain Pluen,Brian Seed,Yves Boucher,Rakesh K. Jain +6 more
TL;DR: It is shown that it is possible to optically image fibrillar collagen in tumors growing in mice using second-harmonic generation (SHG), which could offer basic scientists and clinicians an enhanced ability to estimate the relative penetrabilities of molecular therapeutics.
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Role of tumor-host interactions in interstitial diffusion of macromolecules: cranial vs. subcutaneous tumors.
Alain Pluen,Yves Boucher,Saroja Ramanujan,Trevor D. McKee,Takeshi Gohongi,Emmanuelle di Tomaso,Edward B. Brown,Yotaro Izumi,Robert B. Campbell,David A. Berk,Rakesh K. Jain +10 more
TL;DR: The results point to the necessity of developing site-specific drug carriers to improve the delivery of molecular medicine to solid tumors.
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Diffusion of Macromolecules in Agarose Gels: Comparison of Linear and Globular Configurations
TL;DR: Not only did flexible macromolecules exhibit greater mobility in the gel than did comparable-size rigid spherical particles, they also proved to be a more useful probe of available space between fibers.
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Persistence Length of Single-Stranded DNA
TL;DR: The self-diffusion coefficient of a series of DNA fragments has been measured by fluorescence recovery after photobleaching after thermal denaturation in 8 M urea to deduce the total persistence length p and its variation in ionic strength down to 10-3 M.
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Diffusion and convection in collagen gels: implications for transport in the tumor interstitium.
Saroja Ramanujan,Alain Pluen,Trevor D. McKee,Trevor D. McKee,Edward B. Brown,Yves Boucher,Rakesh K. Jain,Rakesh K. Jain +7 more
TL;DR: Comparison of diffusion and convection data in these gels and tumors suggests that collagen may obstruct diffusion more than convection in tumors, which has significant implications for drug delivery in tumors and for tissue engineering applications.