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Christopher D. Benjamin
Researcher at Biogen Idec
Publications - 87
Citations - 7524
Christopher D. Benjamin is an academic researcher from Biogen Idec. The author has contributed to research in topics: Cell adhesion molecule & Receptor. The author has an hindex of 38, co-authored 87 publications receiving 7371 citations. Previous affiliations of Christopher D. Benjamin include Tufts Medical Center.
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Journal ArticleDOI
BAFF-R, a Newly Identified TNF Receptor That Specifically Interacts with BAFF
Jeffrey Thompson,Sarah A. Bixler,Fang Qian,Kalpit Vora,Martin L. Scott,Teresa G. Cachero,Catherine Hession,Pascal Schneider,Irene Sizing,Colleen Mullen,Kathy Strauch,Mohammad Zafari,Christopher D. Benjamin,Jürg Tschopp,Jeffrey L. Browning,Christine Ambrose +15 more
TL;DR: BAFF-R appears to be the principal receptor for BAFF-mediated mature B cell survival and is disrupted in A/WySnJ mice, which display a B cell phenotype qualitatively similar to that of the BAff-deficient mice.
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Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets.
Theresa M. Palabrica,Roy R. Lobb,Barbara C. Furie,Mark Aronovitz,Christopher D. Benjamin,Yen-Ming Hsu,Susan A. Sajer,Bruce Furie +7 more
TL;DR: Results indicate that P-selectin is an important adhesion molecule on platelets, mediating platelet–leukocyte binding in vivo, that the presence of leukocytes in thrombi is mediated by P- selectin, and that these leukocyte promote fibrin deposition.
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Vascular cell adhesion molecule-1 is expressed in human coronary atherosclerotic plaques. Implications for the mode of progression of advanced coronary atherosclerosis.
Kevin D. O'Brien,Margaret D. Allen,Thomas O. McDonald,Alan Chait,John M. Harlan,Daniel P. Fishbein,John M. McCarty,Marina S. Ferguson,Kelly L. Hudkins,Christopher D. Benjamin +9 more
TL;DR: The results document the presence of VCAM-1 in human atherosclerosis, demonstrate VCAM1 expression by human smooth muscle cells in vivo, and suggest that intimal neovasculature may be an important site of inflammatory cell recruitment into advanced coronary lesions.
Journal ArticleDOI
Requirement for MAP kinase (ERK2) activity in interferon alpha- and interferon beta-stimulated gene expression through STAT proteins
Michael David,Emanuel F. Petricoin,Christopher D. Benjamin,Richard Pine,Michael J. Weber,Andrew C. Larner +5 more
TL;DR: MAPK appears to regulateIFN-alpha and IFN-beta activation of early response genes by modifying the Jak-STAT signaling cascade.
Journal ArticleDOI
Baff Binds to the Tumor Necrosis Factor Receptor–Like Molecule B Cell Maturation Antigen and Is Important for Maintaining the Peripheral B Cell Population
Jeffrey Thompson,Pascal Schneider,Susan L. Kalled,Li Chun Wang,Eric A. Lefevre,Teresa G. Cachero,Fabienne Mackay,Sarah A. Bixler,Mohammad Zafari,Zhong-Ying Liu,Stephen A. Woodcock,Fang Qian,Marcel Batten,Christine Madry,Yolande Richard,Christopher D. Benjamin,Jeffrey L. Browning,Andreas Tsapis,Jürg Tschopp,Christine Ambrose +19 more
TL;DR: A soluble form of BCMA, which inhibited the binding of BAFF to a B cell line, induced a dramatic decrease in the number of peripheral B cells when administered in vivo, consistent with a role for BAFF in maintaining homeostasis of the B cell population.